Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{West:2020:10.1111/aogs.13883,
author = {West, S and Ollila, M-M and Franks, S and Piltonen, T and Jokelainen, J and Nevalainen, J and Puukka, K and Ruokonen, A and Jarvelin, M-R and Auvinen, J and Tapanainen, JS and Morin-Papunen, L},
doi = {10.1111/aogs.13883},
journal = {Acta Obstetricia et Gynecologica Scandinavica},
pages = {1311--1319},
title = {Overweight, obesity and hyperandrogenemia are associated with gestational diabetes mellitus: A follow-up cohort study},
url = {http://dx.doi.org/10.1111/aogs.13883},
volume = {99},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionThe aim of the study was to determine the association of body mass index (BMI), selfreported symptoms or diagnosis of polycystic ovary syndrome (PCOS), and hyperandrogenemia with the occurrence of gestational diabetes mellitus (GDM) through reproductive life.Material and methodsA cohort of women born in 1966 were investigated at ages 14, 31 and 46. Women with selfreported PCOS symptoms (presence of both oligoamenorrhea and hirsutism) at age 31 or with formally diagnosed polycystic ovaries (PCO)/PCOS by age 46 formed the group of selfreported PCOS (srPCOS, n = 222) and were compared with women without selfreported PCOS symptoms or diagnosis (n = 1357). We investigated also the association of hyperandrogenism (hirsutism or biochemical hyperandrogenism) at age 31 with the occurrence of GDM throughout reproductive life.ResultsSelfreported PCOS alone was not a risk factor for GDM, but combined with overweight at age 31 (odds ratio [OR] 2.43, 95% confidence interval [CI] 1.224.86) or 46 (OR 3.04, 95% CI 1.585.83) srPCOS was associated with GDM when compared with normal weight controls. The association disappeared when comparing overweight srPCOS women with overweight controls. However, hyperandrogenemia at age 31, but not hirsutism, was associated with GDM even after adjustment for BMI.ConclusionsThe increased risk of GDM in women with srPCOS was mostly attributed to overweight or obesity. Importantly, normal weight women with srPCOS did not seem to be at increased risk for developing GDM. However, hyperandrogenemia was associated with GDM even after adjustment for BMI. These findings strengthen the importance of weight management in reproductiveage women and suggest a noteworthy role of hyperandrogenemia in the pathophysiology of GDM.
AU  - West,S
AU  - Ollila,M-M
AU  - Franks,S
AU  - Piltonen,T
AU  - Jokelainen,J
AU  - Nevalainen,J
AU  - Puukka,K
AU  - Ruokonen,A
AU  - Jarvelin,M-R
AU  - Auvinen,J
AU  - Tapanainen,JS
AU  - Morin-Papunen,L
DO  - 10.1111/aogs.13883
EP  - 1319
PY  - 2020///
SN  - 0001-6349
SP  - 1311
TI  - Overweight, obesity and hyperandrogenemia are associated with gestational diabetes mellitus: A follow-up cohort study
T2  - Acta Obstetricia et Gynecologica Scandinavica
UR  - http://dx.doi.org/10.1111/aogs.13883
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000536621200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/aogs.13883
UR  - http://hdl.handle.net/10044/1/82358
VL  - 99
ER  -
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