Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lin:2021:10.1021/acsnano.0c05423,
author = {Lin, Y and Penna, M and Spicer, CD and Higgins, SG and Gelmi, A and Kim, N and Wang, S-T and Wojciechowski, JP and Pashuck, ET and Yarovsky, I and Stevens, MM},
doi = {10.1021/acsnano.0c05423},
journal = {ACS Nano},
pages = {4034--4044},
title = {High-throughput peptide derivatization toward supramolecular diversification in microtiter plates},
url = {http://dx.doi.org/10.1021/acsnano.0c05423},
volume = {15},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The evolution of life on earth eventually leads to the emergence of species with increased complexity and diversity. Similarly, evolutionary chemical space exploration in the laboratory is a key step to pursue the structural and functional diversity of supramolecular systems. Here, we present a powerful tool that enables rapid peptide diversification and employ it to expand the chemical space for supramolecular functions. Central to this strategy is the exploitation of palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to direct combinatorial synthesis of peptide arrays in microtiter plates under an open atmosphere. Taking advantage of this in situ library design, our results unambiguously deliver a fertile platform for creating a set of intriguing peptide functions including green fluorescent protein-like peptide emitters with chemically encoded emission colors, hierarchical self-assembly into nano-objects, and macroscopic hydrogels. This work also offers opportunities for quickly surveying the diversified peptide arrays and thereby identifying the structural factors that modulate peptide properties.
AU  - Lin,Y
AU  - Penna,M
AU  - Spicer,CD
AU  - Higgins,SG
AU  - Gelmi,A
AU  - Kim,N
AU  - Wang,S-T
AU  - Wojciechowski,JP
AU  - Pashuck,ET
AU  - Yarovsky,I
AU  - Stevens,MM
DO  - 10.1021/acsnano.0c05423
EP  - 4044
PY  - 2021///
SN  - 1936-0851
SP  - 4034
TI  - High-throughput peptide derivatization toward supramolecular diversification in microtiter plates
T2  - ACS Nano
UR  - http://dx.doi.org/10.1021/acsnano.0c05423
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33587607
UR  - https://pubs.acs.org/doi/10.1021/acsnano.0c05423
UR  - http://hdl.handle.net/10044/1/87149
VL  - 15
ER  -
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