Publications
714 results found
Palmer WL, Bottle A, Davie C, et al., 2013, Weekend Admissions and Increased Risk for Mortality: Less Urgent Treatments Only? <i>Reply</i>, JAMA NEUROLOGY, Vol: 70, Pages: 132-133, ISSN: 2168-6149
Cooke GS, Lemoine M, Thursz M, et al., 2013, Viral hepatitis and the Global Burden of Disease: a need to regroup, Journal of Viral Hepatitis
Lemoine M, Girard P-M, Thursz M, et al., 2012, In the shadow of HIV/AIDS: Forgotten diseases in sub-Saharan Africa: Global health issues and funding agency responsibilities, JOURNAL OF PUBLIC HEALTH POLICY, Vol: 33, Pages: 430-438, ISSN: 0197-5897
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- Citations: 16
Petts G, Dhar A, Kudo H, et al., 2012, Targeted inhibition of Tissue Factor suppresses hepatic fibrosis in CCL4 treated mice, 63rd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 773A-773A, ISSN: 0270-9139
Thursz M, Njie R, Lemoine M, 2012, HEPATITIS Global eradication of hepatitis B - feasible or fallacy?, NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, Vol: 9, Pages: 492-494, ISSN: 1759-5045
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- Citations: 16
Mathurin P, Hadengue A, Bataller R, et al., 2012, EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease, JOURNAL OF HEPATOLOGY, Vol: 57, Pages: 399-420, ISSN: 0168-8278
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- Citations: 487
Rashid ST, Humphries JD, Byron A, et al., 2012, Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver, JOURNAL OF PROTEOME RESEARCH, Vol: 11, Pages: 4052-4064, ISSN: 1535-3893
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- Citations: 62
Antoniades CG, Quaglia A, Taams LS, et al., 2012, Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans, HEPATOLOGY, Vol: 56, Pages: 735-746, ISSN: 0270-9139
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- Citations: 190
Antoniades CG, Zingarelli V, Possamai L, et al., 2012, THE HEPATIC INFLAMMATORY MILIEU OF ACETAMINOPHEN INDUCED ACUTE LIVER FALURE INDUCES ALTERNATIVELY ACTIVATED, M2-LIKE, MACROPHAGES, GUT, Vol: 61, Pages: A183-A183, ISSN: 0017-5749
Petts G, Dhar A, Kudo H, et al., 2012, TARGETED INHIBITION OF TISSUE FACTOR AND THROMBIN ON CD31 EXPRESSING CELLS SUPPRESSES HEPATIC FIBROSIS IN CCL4 TREATED MICE, GUT, Vol: 61, Pages: A28-A28, ISSN: 0017-5749
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- Citations: 1
Vergis N, Antoniades CG, Zingarelli V, et al., 2012, FUNCTIONAL DEFECTS IN CIRCULATING MONOCYTES MAY CONTRIBUTE TO SUSCEPTIBILITY TO INFECTION IN ALCOHOLIC HEPATITIS, GUT, Vol: 61, Pages: A189-A190, ISSN: 0017-5749
Cobbold JFL, Cox IJ, Brown AS, et al., 2012, Lipid profiling of pre-treatment liver biopsy tissue predicts sustained virological response in patients with chronic hepatitis C, Hepatology Research, Vol: 42, Pages: 714-720, ISSN: 1386-6346
Aim: Hepatic lipid is important in the pathogenesis and progression of hepatitis C-related liver disease. Polyunsaturated fatty acids have been shown to reduce viral replication in cell culture. Proton magic angle spinning magnetic resonance spectroscopy (1H MAS MRS) enables metabolic analysis of intact tissue. The aim was to examine the relationship between hepatic lipid composition by metabolic profiling of liver tissue at baseline and treatment response to pegylated-Interferon alfa2 and Ribavirin.Methods: Baseline liver biopsy samples from 31 patients with chronic hepatitis C were analyzed histologically and by 1H MAS MRS. Indices of lipid composition were derived and partial least squares discriminant analysis with cross-validation was used to predict treatment outcome.Results: Of 31 patients, 14 achieved sustained virological response (SVR). Lipid polyunsaturation (median (IQR)) was higher in SVR (3.41% (2.31)) than in treatment failure (TF) (2.15% (1.51)), P = 0.02. Lipid saturation was lower in SVR (85.9% (3.39)) than TF (86.7% (2.17)), P = 0.04. The total lipid content was lower in SVR (1.54% (0.81)) than TF (2.72% (3.47)), P = 0.004. Total choline to lipid ratio was higher in SVR (11.51% (9.99)) than TF (7.5% (6.82)), P = 0.007. Cross-validation correctly predicted the SVR group in 13 of 14 samples with 1 sample misclassified, and the TF group in all 17 samples.Conclusions: Lipid polyunsaturation was greater and total lipid lower in those with SVR, compared with TF. Metabolic profiling of intact liver biopsy samples predicted SVR with high accuracy. Hepatic lipid composition may impact on treatment success.
Levene AP, Kudo H, Armstrong MJ, et al., 2012, Quantifying hepatic steatosis - more than meets the eye, HISTOPATHOLOGY, Vol: 60, Pages: 971-981, ISSN: 0309-0167
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- Citations: 63
Petts G, Dhar A, Kudo H, et al., 2012, TARGETED INHIBITION OF TISSUE FACTOR AND THROMBIN ON CD31 EXPRESSING CELLS SUPPRESSES HEPATIC FIBROSIS IN CCL<sub>4</sub> TREATED MICE, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S157-S157, ISSN: 0168-8278
Cowan M, Garvey LJ, Thomson EC, et al., 2012, NON-CIRRHOTIC PORTAL HYPERTENSION IN HIV INFECTION HAS A VARIED CLINICAL PHENOTYPE AND IS ASSOCIATED WITH DIDANOSINE AND THROMBOPHILIA: REVIEW OF TWENTY-ONE CASES, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S528-S529, ISSN: 0168-8278
Cobbold JFL, Peake CM, Anstee QM, et al., 2012, MEASURING THE EFFECTIVENESS OF A MULTIDISCIPLINARY NON-ALCOHOLIC FATTY LIVER DISEASE CLINIC, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S506-S506, ISSN: 0168-8278
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- Citations: 1
Possamai LA, Harrison M, Cox RD, et al., 2012, <SUP>1</SUP>H-NMR METABOLIC PROFILING IN GERM-FREE AND CONVENTIONALLY HOUSED MOUSE MODELS OF ACETAMINOPHEN-INDUCED HEPATOTOXICITY, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S529-S529, ISSN: 0168-8278
Dhar A, Anstee QM, Sadiq F, et al., 2012, A ROLE FOR ANTICOAGULATION IN FIBROGENESIS: SUPPRESSION OF HUMAN HEPATIC STELLATE CELL CONTRACTILITY AND LIVER FIBROSIS IN VITRO AND VIVO, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S35-S36, ISSN: 0168-8278
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- Citations: 2
Antoniades CG, Zingarelli V, Possamai L, et al., 2012, THE HEPATIC INFLAMMATORY MICROENVIRONMENT INDUCES ENDOTOXIN TOLERANT MONOCYTES IN ACETAMINOPHEN-INDUCED LIVER FAILURE, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S40-S40, ISSN: 0168-8278
Vergis N, Antoniades CG, Zingarelli V, et al., 2012, FUNCTIONAL DEFECTS IN CIRCULATING MONOCYTES MAY CONTRIBUTE TO INCREASED SUSCEPTIBILTY TO INFECTION IN ALCOHOLIC HEPATITIS, International Liver Congress / 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S43-S43, ISSN: 0168-8278
Robinson O, Toledano MB, Goldin R, et al., 2012, HIRMI VALLEY LIVER DISEASE: A TALE OF TWO TOXINS, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S33-S34, ISSN: 0168-8278
Andreou N, Cowan ML, Thomson EC, et al., 2012, ELEVATED ALT IS UBIQUITOUS IN PATIENTS WITH HIV AND FATTY LIVER IS BOTH COMMON AND UNDERDIAGNOSED, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S506-S507, ISSN: 0168-8278
Wiersma ST, McMahon B, Pawlotsky JM, et al., 2012, Treatment of chronic hepatitis B virus infection in resource-constrained settings: expert panel consensus (vol 31, pg 755, 2011), LIVER INTERNATIONAL, Vol: 32, Pages: 174-174, ISSN: 1478-3223
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- Citations: 1
Thursz M, 2012, Get Active, JOURNAL OF HEPATOLOGY, Vol: 56, Pages: 5-6, ISSN: 0168-8278
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- Citations: 1
Watt M, Mealing S, Huerta M, et al., 2011, CURRENT TREATMENTS FOR CHRONIC HEPATITIS B: A SYSTEMATIC REVIEW, VALUE IN HEALTH, Vol: 14, Pages: A392-A392, ISSN: 1098-3015
Dhar A, Kampscheur M, Sadiq F, et al., 2011, COAGULATION PROTEINS IN LIVER FIBROSIS: A ROLE FOR TISSUE FACTOR AND FIBRIN/FIBRINOGEN, GUT, Vol: 60, Pages: A48-A48, ISSN: 0017-5749
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- Citations: 2
Leach L, Cobbold JFL, Valabhji J, et al., 2011, REDUCTION IN ALANINE AMINOTRANSFERASE VALUES IN DIABETIC PATIENTS RECEIVING LONG-TERM ORAL ANTIBIOTICS: DOES MODULATION OF GUT FLORA AFFECT HEPATIC INFLAMMATION IN NON-ALCOHOLIC FATTY LIVER DISEASE?, GUT, Vol: 60, Pages: A13-A13, ISSN: 0017-5749
Peake CM, Cobbold JFL, Anstee QM, et al., 2011, MEASURING THE EFFECTIVENESS OF A MULTIDISCIPLINARY NASH CLINIC, GUT, Vol: 60, Pages: A6-A6, ISSN: 0017-5749
Antoniades CG, Zingarelli V, Possamai L, et al., 2011, MOLECULAR MECHANISMS OF MONOCYTE REPROGRAMMING IN ACUTE LIVER FAILURE: IMPORTANCE OF HEPATICALLY DERIVED ANTI-INFLAMMATORY MEDIATORS, GUT, Vol: 60, Pages: A44-A45, ISSN: 0017-5749
Possamai LA, Quaglia A, Antoniades CG, et al., 2011, APOPTOSIS IN PARACETAMOL-INDUCED ACUTE LIVER FAILURE: IMPORTANCE OF EXTRA-HEPATIC ORGAN DYSFUNCTION, GUT, Vol: 60, Pages: A1-A2, ISSN: 0017-5749
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- Citations: 1
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