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@article{Freitas:2024:10.1371/journal.pntd.0011882,
author = {Freitas, LT and Khan, MA and Uddin, A and Halder, JB and Singh-Phulgenda, S and Raja, JD and Balakrishnan, V and Harriss, E and Rahi, M and Brack, M and Guérin, PJ and Basáñez, M-G and Kumar, A and Walker, M and Srividya, A},
doi = {10.1371/journal.pntd.0011882},
journal = {PLoS Neglected Tropical Diseases},
title = {The lymphatic filariasis treatment study landscape: a systematic review of study characteristics and the case for an individual participant data platform},
url = {http://dx.doi.org/10.1371/journal.pntd.0011882},
volume = {18},
year = {2024}
}

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TY  - JOUR
AB  - BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease (NTD) targeted by the World Health Organization for elimination as a public health problem (EPHP). Since 2000, more than 9 billion treatments of antifilarial medicines have been distributed through mass drug administration (MDA) programmes in 72 endemic countries and 17 countries have reached EPHP. Yet in 2021, nearly 900 million people still required MDA with combinations of albendazole, diethylcarbamazine and/or ivermectin. Despite the reliance on these drugs, there remain gaps in understanding of variation in responses to treatment. As demonstrated for other infectious diseases, some urgent questions could be addressed by conducting individual participant data (IPD) meta-analyses. Here, we present the results of a systematic literature review to estimate the abundance of IPD on pre- and post-intervention indicators of infection and/or morbidity and assess the feasibility of building a global data repository. METHODOLOGY: We searched literature published between 1st January 2000 and 5th May 2023 in 15 databases to identify prospective studies assessing LF treatment and/or morbidity management and disease prevention (MMDP) approaches. We considered only studies where individual participants were diagnosed with LF infection or disease and were followed up on at least one occasion after receiving an intervention/treatment. PRINCIPAL FINDINGS: We identified 138 eligible studies from 23 countries, having followed up an estimated 29,842 participants after intervention. We estimate 14,800 (49.6%) IPD on pre- and post-intervention infection indicators including microfilaraemia, circulating filarial antigen and/or ultrasound indicators measured before and after intervention using 8 drugs administered in various combinations. We identified 33 studies on MMDP, estimating 6,102 (20.4%) IPD on pre- and post-intervention clinical morbidity indicators only. A further 8,940 IPD cover a mixture of infection and
AU  - Freitas,LT
AU  - Khan,MA
AU  - Uddin,A
AU  - Halder,JB
AU  - Singh-Phulgenda,S
AU  - Raja,JD
AU  - Balakrishnan,V
AU  - Harriss,E
AU  - Rahi,M
AU  - Brack,M
AU  - Guérin,PJ
AU  - Basáñez,M-G
AU  - Kumar,A
AU  - Walker,M
AU  - Srividya,A
DO  - 10.1371/journal.pntd.0011882
PY  - 2024///
SN  - 1935-2727
TI  - The lymphatic filariasis treatment study landscape: a systematic review of study characteristics and the case for an individual participant data platform
T2  - PLoS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0011882
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38227595
UR  - https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011882
UR  - http://hdl.handle.net/10044/1/110277
VL  - 18
ER  -

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