Imperial College London
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Professor Martin Wilkins

Faculty of Medicine, National Heart & Lung Institute

Professor of Clinical Pharmacology
 
 
 
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Contact

 

+44 (0)20 3313 6101m.wilkins Website

 
 
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Assistant

 

Mrs Elizabeth O'Brien +44 (0)20 3313 6101

 
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Location

 

NIHR Imperial Clinical Research FacilityICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wilkins:2002,
author = {Wilkins, MR and Møller, GMO and Ren, X and Wharton, J},
journal = {Minerva Cardioangiol},
pages = {175--187},
title = {Developments in therapeutics for pulmonary arterial hypertension.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/12107399},
volume = {50},
year = {2002}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - For many years, the management of pulmonary hypertension has been frustrated by an inadequate understanding of its pathology and limited therapeutic options, but this is changing rapidly. Recently, novel insight into the pathogenesis of primary pulmonary hypertension (PPH) has been provided by the demonstration of mutations in BMPR2 and ALK-1 genes in a significant number of patients with the condition. These genes encode members of the TGF-b receptor superfamily and their integrity is important in the maintenance of normal pulmonary vascular structure and function. At the same time, there has been a major advance in the treatment of the condition due to development of 2 orally active pharmacological agents, bosentan and sildenafil, which demonstrate some selectivity for the pulmonary vasculature. This review examines how the management of PPH and severe pulmonary hypertension in associated diseases has changed and looks at exciting future developments.
AU  - Wilkins,MR
AU  - Møller,GMO
AU  - Ren,X
AU  - Wharton,J
EP  - 187
PY  - 2002///
SN  - 0026-4725
SP  - 175
TI  - Developments in therapeutics for pulmonary arterial hypertension.
T2  - Minerva Cardioangiol
UR  - https://www.ncbi.nlm.nih.gov/pubmed/12107399
VL  - 50
ER  -
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