Imperial College London
Alternate

ProfessorMarkJohnson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Chair in Obstetrics
 
 
 
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Contact

 

+44 (0)20 3315 7887mark.johnson

 
 
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Location

 

H3.35Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shah:2019:10.3389/fendo.2019.00198,
author = {Shah, NM and Lai, PF and Imami, N and Johnson, MR},
doi = {10.3389/fendo.2019.00198},
journal = {Frontiers in endocrinology},
title = {Progesterone-Related Immune Modulation of Pregnancy and Labor.},
url = {http://dx.doi.org/10.3389/fendo.2019.00198},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pregnancy involves a complex interplay between maternal neuroendocrine and immunological systems in order to establish and sustain a growing fetus. It is thought that the uterus at pregnancy transitions from quiescent to laboring state in response to interactions between maternal and fetal systems at least partly <i>via</i> altered neuroendocrine signaling. Progesterone (P4) is a vital hormone in maternal reproductive tissues and immune cells during pregnancy. As such, P4 is widely used in clinical interventions to improve the chance of embryo implantation, as well as reduce the risk of miscarriage and premature labor. Here we review research to date that focus on the pathways through which P4 mediates its actions on both the maternal reproductive and immune system. We will dissect the role of P4 as a modulator of inflammation, both systemic and intrinsic to the uterus, during human pregnancy and labor.
AU  - Shah,NM
AU  - Lai,PF
AU  - Imami,N
AU  - Johnson,MR
DO  - 10.3389/fendo.2019.00198
PY  - 2019///
SN  - 1664-2392
TI  - Progesterone-Related Immune Modulation of Pregnancy and Labor.
T2  - Frontiers in endocrinology
UR  - http://dx.doi.org/10.3389/fendo.2019.00198
UR  - http://hdl.handle.net/10044/1/68544
VL  - 10
ER  -
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