Imperial College London

DrMichaelCox

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 7974michael.cox1 Website

 
 
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Location

 

413Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cox:2010,
author = {Cox, MJ and Allgaier, M and Taylor, B and Baek, MS and Huang, YJ and Daly, RA and Karaoz, U and Andersen, GL and Brown, R and Fujimura, KE and Wu, B and Tran, D and Koff, J and Kleinhenz, ME and Nielson, D and Brodie, EL and Lynch, SV},
journal = {PloS one},
pages = {e11044--e11044},
title = {Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients.},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2890402&tool=pmcentrez&rendertype=abstract},
volume = {5},
year = {2010}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Bacterial communities in the airways of cystic fibrosis (CF) patients are, as in other ecological niches, influenced by autogenic and allogenic factors. However, our understanding of microbial colonization in younger versus older CF airways and the association with pulmonary function is rudimentary at best. Using a phylogenetic microarray, we examine the airway microbiota in age stratified CF patients ranging from neonates (9 months) to adults (72 years). From a cohort of clinically stable patients, we demonstrate that older CF patients who exhibit poorer pulmonary function possess more uneven, phylogenetically-clustered airway communities, compared to younger patients. Using longitudinal samples collected form a subset of these patients a pattern of initial bacterial community diversification was observed in younger patients compared with a progressive loss of diversity over time in older patients. We describe in detail the distinct bacterial community profiles associated with young and old CF patients with a particular focus on the differences between respective "early" and "late" colonizing organisms. Finally we assess the influence of Cystic Fibrosis Transmembrane Regulator (CFTR) mutation on bacterial abundance and identify genotype-specific communities involving members of the Pseudomonadaceae, Xanthomonadaceae, Moraxellaceae and Enterobacteriaceae amongst others. Data presented here provides insights into the CF airway microbiota, including initial diversification events in younger patients and establishment of specialized communities of pathogens associated with poor pulmonary function in older patient populations.
AU - Cox,MJ
AU - Allgaier,M
AU - Taylor,B
AU - Baek,MS
AU - Huang,YJ
AU - Daly,RA
AU - Karaoz,U
AU - Andersen,GL
AU - Brown,R
AU - Fujimura,KE
AU - Wu,B
AU - Tran,D
AU - Koff,J
AU - Kleinhenz,ME
AU - Nielson,D
AU - Brodie,EL
AU - Lynch,SV
EP - 11044
PY - 2010///
SP - 11044
TI - Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients.
T2 - PloS one
UR - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2890402&tool=pmcentrez&rendertype=abstract
UR - file:///Users/mike/Documents/Mendeley%20Desktop/PloS%20one/2010/Cox%20et%20al/Cox%20et%20al._2010_Airway%20microbiota%20and%20pathogen%20abundance%20in%20age-stratified%20cystic%20fibrosis%20patients.pdf
VL - 5
ER -