Imperial College London
Alternate

Michael A Crawford PhD, FRSB, FRCPath

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)7725 250 541michael.crawford Website CV

 
 
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Location

 

H 3.34Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Phylactos:1995:10.1111/j.1651-2227.1995.tb13580.x,
author = {Phylactos, AC and Leaf, AA and Costeloe, K and Crawford, MA},
doi = {10.1111/j.1651-2227.1995.tb13580.x},
journal = {Acta Paediatr},
pages = {1421--1425},
title = {Erythrocyte cupric/zinc superoxide dismutase exhibits reduced activity in preterm and low-birthweight infants at birth.},
url = {http://dx.doi.org/10.1111/j.1651-2227.1995.tb13580.x},
volume = {84},
year = {1995}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In a comparative study in term, preterm and low-birthweight infants, the mean activity and standard error of the mean for copper/zinc superoxide dismutase (Cu/Zn SOD) in cord erythrocytes from five term small for gestational age infants was 0.94 +/- 0.10 SOD units (mg protein)-1. This value was significantly lower than the activity (2.34 +/- 0.24) in nine term, appropriate for gestational age (AGA) babies (p < 0.005). In 15 preterm (AGA) infants, the activity at birth (1.05 +/- 0.07 SOD units (mg protein)-1) was also significantly lower (p < 0.001) relative to term AGA babies. An increased level of activity (1.59 +/- 0.09) was detected in the red cells of eight preterm AGA infants on their expected date of delivery compared with (0.87 +/- 0.06) at birth (p < 0.001). However, the activity (1.59 +/- 0.09) was still lower than that detected in term AGA babies (2.34 +/- 0.24; p < 0.02). Similar findings were obtained when enzymatic activity was expressed in units per millilitre of packed erythrocytes. The low activity of Cu/Zn SOD in preterm and low-birthweight babies may render them susceptible to diseases associated with membrane lipid peroxidation.
AU  - Phylactos,AC
AU  - Leaf,AA
AU  - Costeloe,K
AU  - Crawford,MA
DO  - 10.1111/j.1651-2227.1995.tb13580.x
EP  - 1425
PY  - 1995///
SN  - 0803-5253
SP  - 1421
TI  - Erythrocyte cupric/zinc superoxide dismutase exhibits reduced activity in preterm and low-birthweight infants at birth.
T2  - Acta Paediatr
UR  - http://dx.doi.org/10.1111/j.1651-2227.1995.tb13580.x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/8645962
VL  - 84
ER  -
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