Imperial College London
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DrNiklasFeldhahn

Faculty of Medicine, Department of Immunology and Inflammation

Senior Lecturer in Molecular Haematology
 
 
 
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Contact

 

+44 (0)20 3313 1528n.feldhahn Website

 
 
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Location

 

, 4N3DCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Su:2004:10.1002/eji.200425445,
author = {Su, YW and Herzog, S and Lotz, M and Feldhahn, N and Muschen, M and Jumaa, H},
doi = {10.1002/eji.200425445},
journal = {Eur J Immunol},
pages = {3614--3622},
title = {The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion},
url = {http://dx.doi.org/10.1002/eji.200425445},
volume = {34},
year = {2004}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Successful recombination of the heavy-chain locus in developing B cells results in the expression of the pre-BCR, which induces the proliferation and expansion of pre-B cells. To avoid uncontrolled proliferation, pre-BCR signals transmitted via the adaptor protein SLP-65 (SH2-domain-containing leukocyte protein of 65 kDa) lead to the down-regulation of pre-BCR expression and to pre-B cell differentiation. Here, we show that, similarly to SLP-65, the adaptor protein LAT (linker for activation of T cells) limits pre-B cell proliferation and reduces the potential of a tumorgenic pre-B cell line to develop leukemia in immune-deficient mice. We further show that the four distal tyrosines are required for LAT activity in pre-B cells. Mutation at Y136 completely abolishes LAT activity, whereas single point-mutations at Y175, Y195 or Y235 impair, but do not block, LAT-induced pre-B cell differentiation. As LAT is also expressed in human pre-B cells, our results suggest that LAT cooperates with SLP-65 to promote the differentiation and control the proliferation of both murine and human pre-B cells.
AU  - Su,YW
AU  - Herzog,S
AU  - Lotz,M
AU  - Feldhahn,N
AU  - Muschen,M
AU  - Jumaa,H
DO  - 10.1002/eji.200425445
EP  - 3622
PY  - 2004///
SN  - 0014-2980
SP  - 3614
TI  - The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion
T2  - Eur J Immunol
UR  - http://dx.doi.org/10.1002/eji.200425445
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15549729
VL  - 34
ER  -
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