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@article{Kogler:2004:10.1084/jem.20040440,
author = {Kogler, G and Sensken, S and Airey, JA and Trapp, T and Muschen, M and Feldhahn, N and Liedtke, S and Sorg, RV and Fischer, J and Rosenbaum, C and Greschat, S and Knipper, A and Bender, J and Degistirici, O and Gao, J and Caplan, AI and Colletti, EJ and Almeida-Porada, G and Muller, HW and Zanjani, E and Wernet, P},
doi = {10.1084/jem.20040440},
journal = {J Exp Med},
pages = {123--135},
title = {A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential},
url = {http://dx.doi.org/10.1084/jem.20040440},
volume = {200},
year = {2004}
}

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TY  - JOUR
AB  - Here a new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described. This rare population grows adherently and can be expanded to 10(15) cells without losing pluripotency. In vitro USSCs showed homogeneous differentiation into osteoblasts, chondroblasts, adipocytes, and hematopoietic and neural cells including astrocytes and neurons that express neurofilament, sodium channel protein, and various neurotransmitter phenotypes. Stereotactic implantation of USSCs into intact adult rat brain revealed that human Tau-positive cells persisted for up to 3 mo and showed migratory activity and a typical neuron-like morphology. In vivo differentiation of USSCs along mesodermal and endodermal pathways was demonstrated in animal models. Bony reconstitution was observed after transplantation of USSC-loaded calcium phosphate cylinders in nude rat femurs. Chondrogenesis occurred after transplanting cell-loaded gelfoam sponges into nude mice. Transplantation of USSCs in a noninjury model, the preimmune fetal sheep, resulted in up to 5% human hematopoietic engraftment. More than 20% albumin-producing human parenchymal hepatic cells with absence of cell fusion and substantial numbers of human cardiomyocytes in both atria and ventricles of the sheep heart were detected many months after USSC transplantation. No tumor formation was observed in any of these animals.
AU  - Kogler,G
AU  - Sensken,S
AU  - Airey,JA
AU  - Trapp,T
AU  - Muschen,M
AU  - Feldhahn,N
AU  - Liedtke,S
AU  - Sorg,RV
AU  - Fischer,J
AU  - Rosenbaum,C
AU  - Greschat,S
AU  - Knipper,A
AU  - Bender,J
AU  - Degistirici,O
AU  - Gao,J
AU  - Caplan,AI
AU  - Colletti,EJ
AU  - Almeida-Porada,G
AU  - Muller,HW
AU  - Zanjani,E
AU  - Wernet,P
DO  - 10.1084/jem.20040440
EP  - 135
PY  - 2004///
SN  - 0022-1007
SP  - 123
TI  - A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
T2  - J Exp Med
UR  - http://dx.doi.org/10.1084/jem.20040440
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15263023
VL  - 200
ER  -

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