Imperial College London
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DrNeilHill

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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n.hill

 
 
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Location

 

East WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hill:2018:10.1249/MSS.0000000000001624,
author = {Hill, NE and Deighton, K and Matu, J and Misra, S and Oliver, NS and Newman, C and Mellor, A and O'Hara, J and Woods, D},
doi = {10.1249/MSS.0000000000001624},
journal = {Med Sci Sports Exerc},
pages = {1679--1686},
title = {Continuous Glucose Monitoring at High Altitude-Effects on Glucose Homeostasis.},
url = {http://dx.doi.org/10.1249/MSS.0000000000001624},
volume = {50},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PURPOSE: Exposure to high altitude has been shown to enhance both glucose and lipid utilization depending on experimental protocol. In addition, high and low blood glucose levels have been reported at high altitude. We hypothesized that gradual ascent to high altitude results in changes in glucose levels in healthy young adults. METHODS: Twenty-five adult volunteers, split into two teams, took part in the British Services Dhaulagiri Medical Research Expedition completing 14 d of trekking around the Dhaulagiri circuit in Nepal reaching a peak altitude of 5300 m on day 11 of the trek. Participants wore blinded continuous glucose monitors (CGM) throughout. Blood samples for C-peptide, proinsulin, and triacylglycerides were taken at sea level (United Kingdom) and in acclimatization camps at 3600, 4650, and 5120 m. Energy intake was determined from food diaries. RESULTS: There was no difference in time spent in hypoglycemia stratified by altitude. Nocturnal CGM readings (2200-0600 h) were chosen to reduce the short-term effect of physical activity and food intake and showed a significant (P < 0.0001) increase at 3600 m (5.53 ± 0.22 mmol·L), 4650 m (4.77 ± 0.30 mmol·L), and 5120 m (4.78 ± 0.24 mmol·L) compared with baseline altitude 1100 m (vs 4.61 ± 0.25 mmol·L). Energy intake did not differ by altitude. Insulin resistance and beta-cell function, calculated by homeostatic model assessment, were reduced at 3600 m compared with sea level. CONCLUSIONS: We observed a significant increase in nocturnal CGM glucose at 3600 m and greater despite gradual ascent from 1100 m. Taken with the changes in insulin resistance and beta-cell function, it is possible that the stress response to high altitude dominates exercise-enhanced insulin sensitivity, resulting in relative hyperglycemia.
AU  - Hill,NE
AU  - Deighton,K
AU  - Matu,J
AU  - Misra,S
AU  - Oliver,NS
AU  - Newman,C
AU  - Mellor,A
AU  - O'Hara,J
AU  - Woods,D
DO  - 10.1249/MSS.0000000000001624
EP  - 1686
PY  - 2018///
SP  - 1679
TI  - Continuous Glucose Monitoring at High Altitude-Effects on Glucose Homeostasis.
T2  - Med Sci Sports Exerc
UR  - http://dx.doi.org/10.1249/MSS.0000000000001624
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29613998
UR  - http://hdl.handle.net/10044/1/60185
VL  - 50
ER  -
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