Publications
143 results found
Boshier PR, Mistry V, Cushnir JR, et al., 2013, Towards molecular assessment of surgical metabolic response: Exhaled breath signatures of major upper gastrointestinal surgery, Joint Meeting of the Section-of-Surgery of the Royal-Society-of-Medicine / Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 47-47, ISSN: 0007-1323
Boshier PR, Hanna GB, Marczin N, 2013, Exhaled nitric oxide as biomarker of acute lung injury: an unfulfilled promise?, J Breath Res, Vol: 7
The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflammation such as asthma that affects millions worldwide, exhaled NO has achieved spectacular successes with patients currently owning handheld devices and monitoring inflammatory aspects of their conditions in their own homes. This has been facilitated by recognition by regulatory bodies, scientific and clinical societies and insurance companies. While characteristic changes in exhaled NO have also been observed in acute lung injury (ALI), the promise of exhaled NO as a surrogate biomarker of this life-threatening disease has not been achieved. In this work, we have analysed factors contributing to successes of exhaled NO in the asthma field and contrasted these on the ALI field. We provide a snapshot of current status of exhaled NO field in ALI and propose a framework for definite evaluation of exhaled NO as a clinically useful biomarker.
Kuppuswamy M, Popov AF, Carby M, et al., 2012, Bilateral Lobar Lung Transplantation Using H1N1-Positive Lungs in the Presence of Anti-HLA Antibodies, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 108-109, ISSN: 1073-449X
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- Citations: 2
Zych B, Popov AF, Stavri G, et al., 2012, Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 31, Pages: 274-281, ISSN: 1053-2498
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- Citations: 100
Boshier PR, Priest OH, Hanna GB, et al., 2011, Influence of respiratory variables on the on-line detection of exhaled trace gases by PTR-MS, THORAX, Vol: 66, Pages: 919-920, ISSN: 0040-6376
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- Citations: 24
Potapov E, Meyer D, Swaminathan M, et al., 2011, Inhaled nitric oxide after left ventricular assist device implantation: A prospective, randomized, double-blind, multicenter, placebo-controlled trial, JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 30, Pages: 870-878, ISSN: 1053-2498
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- Citations: 76
Roeth E, Marczin N, Balatonyi B, et al., 2011, Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes, EXPERIMENTAL & CLINICAL CARDIOLOGY, Vol: 16, Pages: 92-96
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- Citations: 33
Korovesi I, Papadomichelakis E, Orfanos SE, et al., 2011, Exhaled breath condensate in mechanically ventilated brain-injured patients with no lung injury or sepsis., Anesthesiology, Vol: 114, Pages: 1118-1129
BACKGROUND: The inflammatory influence of prolonged mechanical ventilation in uninjured lungs remains a matter of controversy and largely unexplored in humans. The authors investigated pulmonary inflammation by using exhaled breath condensate (EBC) in mechanically ventilated, brain-injured patients in the absence of acute lung injury or sepsis and explored the potential influence of positive end-expiratory pressure (PEEP). METHODS: Inflammatory EBC markers were assessed in 27 mechanically ventilated, brain-injured patients with neither acute lung injury nor sepsis and in 12 healthy and 8 brain-injured control subjects. Patients were ventilated with 8 ml/kg during zero end-expiratory pressure (ZEEP group, n = 12) or 8 cm H(2)O PEEP (PEEP group, n = 15). EBC was collected on days 1, 3, and 5 of mechanical ventilation to measure pH; interleukins (IL)-10, 1β, 6, 8, and 12p70; and tumor necrosis factor-α. RESULTS: EBC pH was lower, whereas IL-1β and tumor necrosis factor-α were greater in both patient groups compared with either control group; IL-6 was higher, whereas IL-10 and IL-12p70 were sporadically higher than in healthy control subjects; no differences were noted between the two patient groups, except for IL-10, which decreased by day 5 during PEEP. Leukocytes, soluble IL-6, and soluble triggering receptor expressed on myeloid cells-1 in blood were constantly higher during zero end-expiratory pressure; EBC cytokines appeared mostly related to soluble IL-8 and inversely related to soluble triggering receptor expressed on myeloid cells-1. CONCLUSIONS: In brain-injured, mechanically ventilated patients with neither acute lung injury nor sepsis, EBC markers appear to indicate the presence of subtle pulmonary inflammation that is mostly unaffected by PEEP. There is evidence for a systemic inflammatory response, especially in patients during zero end-expiratory pressure.
Bertok S, Wilson MR, Dorr AD, et al., 2011, Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol: 300, Pages: L781-L789, ISSN: 1040-0605
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- Citations: 22
Boshier PR, Mistry V, Cushnir JR, et al., 2010, ANALYSIS OF VOLATILE BIOMARKERS WITHIN EXHALED BREATH FOR THE DIAGNOSIS OF PNEUMONIA, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A58-A59, ISSN: 0040-6376
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- Citations: 1
Varga T, Kovesi T, Gal J, et al., 2010, Endogenous and nitrovasodilator-induced release of NO in the airways of end-stage cystic fibrosis patients, EUROPEAN RESPIRATORY JOURNAL, Vol: 36, Pages: 682-683, ISSN: 0903-1936
Boshier PR, Cushnir JR, Priest OH, et al., 2010, Variation in the levels of volatile trace gases within three hospital environments: implications for clinical breath testing, JOURNAL OF BREATH RESEARCH, Vol: 4, ISSN: 1752-7155
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- Citations: 22
Boshier PR, Marczin N, Hanna GB, 2010, Repeatability of the Measurement of Exhaled Volatile Metabolites Using Selected Ion Flow Tube Mass Spectrometry, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol: 21, Pages: 1070-1074, ISSN: 1044-0305
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- Citations: 45
Kovacs V, Balatonyi B, Ghosh S, et al., 2010, Effect of oxidative stress of Glutathione S-tranferase in cardiomyocyte cell culture, 45th Congress of the European-Society-for-Surgical-Research, Publisher: JOHN WILEY & SONS LTD, Pages: S96-S97, ISSN: 0007-1323
Balatonyi B, Kovacs V, Takacs I, et al., 2010, Role of Glutathione S-tranferase in the signal pathways in cardiac myocytes under oxidative stress conditions, 45th Congress of the European-Society-for-Surgical-Research, Publisher: JOHN WILEY & SONS LTD, Pages: S96-S96, ISSN: 0007-1323
Fletcher M, Boshier P, Smolenski RT, et al., 2009, MOLECULAR MECHANISMS OF LUNG EPITHELIAL CELL INJURY INDUCED BY INHIBITION OF GLUTATHIONE-<i>S</i>-TRANSFERASE, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A38-A39, ISSN: 0040-6376
Bertok S, Wilson MR, Dokpesi J, et al., 2009, Tumour Necrosis Factor-α (TNF) Receptor p75 Plays a Substantial Role in TNF-Mediated Upregulation of Leukocyte Adhesion Molecules in Mouse Lung Microvasculature, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Fletcher M, Takata M, Marczin N, 2009, Inhibitors of Glutathione-S-Transferase (GST) Induce Cell Death in Lung Epithelial Cells., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Fletcher M, Takata M, Marczin N, 2009, Differential Sensitivity of Mouse (MLE) and Human (A549) Lung Alveolar Epithelial Cells to GST Inhibition and Oxidative Stress., Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Boshier PR, Hanna GB, Marczin N, 2009, Influence of CO2-Triggered "Alveolar" Breath Sampling on the Concentrations of Exhaled Volatile Organic Compounds (VOCs)., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Boshier P, Priest O, Hanna G, et al., 2009, Influence of Respiratory Manoeuvres on the On-Line Detection of Volatile Organic Compounds (VOCs) in Exhaled Breath by PTR-MS and SIFT-MS., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
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- Citations: 2
Fletcher M, Takata M, Marczin N, 2008, INHIBITORS OF GLUTATHIONE-S-TRANSFERASE INDUCE CELL DEATH IN LUNG EPITHELIAL CELLS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A144-A144, ISSN: 0040-6376
Bertok S, Wilson MR, Dokpesi J, et al., 2008, ROLE OF TUMOUR NECROSIS FACTOR a RECEPTOR SUBTYPES IN TUMOUR NECROSIS FACTOR-INDUCED MOUSE LUNG MICROVASCULAR ENDOTHELIAL CELL ACTIVATION, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A141-A141, ISSN: 0040-6376
Farkasfalvi K, Stagg MA, Coppen SR, et al., 2007, Direct effects of apelin on cardiomyocyte contractility and electrophysiology, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 357, Pages: 889-895, ISSN: 0006-291X
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- Citations: 122
Gal J, Kovesi T, Royston D, et al., 2007, Dynamics of nitroglycerin-induced exhaled nitric oxide following lung transplantation: Evidence of pulmonary microvascular injury?, Journal of Heart and Lung Transplantation
Hoare GS, Birks EJ, Bowles C, et al., 2006, In vitro endothelial cell activation and inflammatory responses in end-stage heart failure, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 101, Pages: 1466-1473, ISSN: 8750-7587
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- Citations: 6
Farkasfalvi K, Felkin L, Latif N, et al., 2006, The apelin receptor mRNA levels and myocardial recovery in end-stage heart failure patients treated with left ventricular assist devices (LVADs), 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 484-484, ISSN: 0009-7322
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- Citations: 1
Farkasfalvi K, Stagg MA, Siedlecka U, et al., 2006, Apelin, the ligand for the angiotensin receptor-like 1, directly affects cardiomyocyte contractility and electrophysiology, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 300-300, ISSN: 0009-7322
Felkin LE, Farkasfalvi K, Soppa GKR, et al., 2006, The apelin-angiotensin receptor-like 1 (APJ) mRNA levels closely correlate with myocardial recovery in end-stage heart failure patients treated with left ventricular assist devices (LVADs), 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 267-267, ISSN: 0195-668X
Farkasfalvi K, Stagg MA, Siedlecka U, et al., 2006, Direct effects of apelin, the ligand for the angiotensin receptor-like 1, on cardiomyocyte contractility and electrophysiology, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 407-407, ISSN: 0195-668X
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