Imperial College London
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ProfessorNeenaModi

Faculty of Medicine, School of Public Health

Vice-Dean (International Activities) Faculty of Medicine
 
 
 
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Contact

 

+44 (0)20 3315 5102n.modi Website

 
 
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Assistant

 

Miss Angela Rochester +44 (0)20 7594 0937

 
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Location

 

G4.2Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gemmell:2016:10.1038/jp.2016.133,
author = {Gemmell, L and Martin, L and Murphy, KE and Modi, N and Håkansson, S and Reichman, B and Lui, K and Kusuda, S and Sjörs, G and Mirea, L and Darlow, BA and Mori, R and Lee, SK and Shah, PS},
doi = {10.1038/jp.2016.133},
journal = {Journal of Perinatology},
title = {Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation.},
url = {http://dx.doi.org/10.1038/jp.2016.133},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To examine the relationship between hypertensive disorders of pregnancy (HDPs) and mortality and major morbidities in preterm neonates born at 24 to 28 weeks of gestation. STUDY DESIGN: Using an international cohort, we retrospectively studied 27 846 preterm neonates born at 24(0) to 28(6) weeks of gestation during 2007 to 2010 from 6 national neonatal databases. The incidence of HDP was compared across countries, and multivariable logistic regression analyses were conducted to examine the association of HDP and neonatal outcomes including mortality to discharge, bronchopulmonary dysplasia, severe brain injury, necrotizing enterocolitis and treated retinopathy of prematurity. RESULTS: The incidence of HDP in the entire cohort was 13% (range 11 to 16% across countries). HDP was associated with reduced odds of mortality (adjusted odds ratio (aOR) 0.77; 95% confidence interval (CI) 0.67 to 0.88), severe brain injury (aOR 0.74; 95% CI 0.62 to 0.89) and treated retinopathy (aOR 0.82; 95% CI 0.70 to 0.96), but increased odds of bronchopulmonary dysplasia (aOR 1.16; 95% CI 1.05 to 1.27). CONCLUSIONS: In comparison with neonates born to mothers without HDP, neonates of HDP mothers had lower odds of mortality, severe brain injury and treated retinopathy, but higher odds of bronchopulmonary dysplasia. The impact of maternal HDP on newborn outcomes was inconsistent across outcomes and among countries; therefore, further international collaboration to standardize terminology, case definition and data capture is warranted.Journal of Perinatology advance online publication, 1 September 2016; doi:10.1038/jp.2016.133.
AU  - Gemmell,L
AU  - Martin,L
AU  - Murphy,KE
AU  - Modi,N
AU  - Håkansson,S
AU  - Reichman,B
AU  - Lui,K
AU  - Kusuda,S
AU  - Sjörs,G
AU  - Mirea,L
AU  - Darlow,BA
AU  - Mori,R
AU  - Lee,SK
AU  - Shah,PS
DO  - 10.1038/jp.2016.133
PY  - 2016///
SN  - 1476-5543
TI  - Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation.
T2  - Journal of Perinatology
UR  - http://dx.doi.org/10.1038/jp.2016.133
ER  -
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