Imperial College London
Alternate

ProfessorNadiaRosenthal

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science&ScientificDirector
 
 
 
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Contact

 

+44 (0)20 7594 2737n.rosenthal

 
 
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Location

 

424W2ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sattler:2016:10.1016/j.bbamcr.2016.01.011,
author = {Sattler, S and Rosenthal, N},
doi = {10.1016/j.bbamcr.2016.01.011},
journal = {BBA - Molecular Cell Research},
pages = {1813--1821},
title = {The neonate versus adult mammalian immune system in cardiac repair and regeneration},
url = {http://dx.doi.org/10.1016/j.bbamcr.2016.01.011},
volume = {1863},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The immune system is a crucial player in tissue homeostasis and woundhealing. A sophisticated cascade of events triggered upon injury ensuresprotection from infection and initiates and orchestrates healing. While theneonatal mammal can readily regenerate damaged tissues, adult regenerativecapacity is limited to specific tissue types, and in organs such as the heart,adult wound healing results in fibrotic repair and loss of function. Growingevidence suggests that the immune system greatly influences the balancebetween regeneration and fibrotic repair. The neonate mammalian immunesystem has impaired pro-inflammatory function, is prone to T-helper type 2responses and has an immature adaptive immune system skewed towardsregulatory T cells. While these characteristics make infants susceptible toinfection and prone to allergies, it may also provide an immunologicalenvironment permissive of regeneration.In this review we will give a comprehensive overview of the immune cellsinvolved in healing and regeneration of the heart and explore differencesbetween the adult and neonate immune system that may explain differencesin regenerative ability.
AU  - Sattler,S
AU  - Rosenthal,N
DO  - 10.1016/j.bbamcr.2016.01.011
EP  - 1821
PY  - 2016///
SN  - 0167-4889
SP  - 1813
TI  - The neonate versus adult mammalian immune system in cardiac repair and regeneration
T2  - BBA - Molecular Cell Research
UR  - http://dx.doi.org/10.1016/j.bbamcr.2016.01.011
UR  - http://hdl.handle.net/10044/1/29036
VL  - 1863
ER  -
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