Imperial College London
Alternate

ProfessorNadiaRosenthal

Faculty of Medicine, National Heart & Lung Institute

Chair in Cardiovascular Science&ScientificDirector
 
 
 
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Contact

 

+44 (0)20 7594 2737n.rosenthal

 
 
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Location

 

424W2ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sattler:2017:10.1038/s41536-017-0022-3,
author = {Sattler, S and Fairchild, P and Watt, F and Rosenthal, N and Harding, S},
doi = {10.1038/s41536-017-0022-3},
journal = {npj Regenerative Medicine},
title = {The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?},
url = {http://dx.doi.org/10.1038/s41536-017-0022-3},
volume = {2},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The regenerative capacity of adult human tissues and organs is limited, but recent developments  have seen  the  advent of promising  new technologies  for regenerative therapy. The human heart is of particular interest for regenerative medicine, as cardiac tissue damage is  repaired  by  the  formation  of  rigid  scar  tissue,  which causes inevitable  structural  changes and  progressive  functional  decline leading  to  heart  failure. Cardiac  regenerative  medicine aims to prevent scar formation or replace existing scars to halt or reverse adverse remodeling and  therapeutic  approaches  include the use  of  biomaterials, gene  therapies, delivery  of growth factors and (stem) cell therapies. Regenerative  therapies, however, face significant  obstacles in a hostile  microenvironment. While the early immune response to a myocardial infarct is essential to ensure tissue integrity and to  avoid  fatal  cardiac  rupture, excessive activation  of  endogenous  repair  mechanisms may lead to ongoing inflammation, fibrosis  and sustained autoimmune-mediated tissue damage. Anti-cardiac auto-reactivity of the adaptive immune system has been suggested to be involved in structural remodeling, functional decline and the development of heart failure. It  is, therefore, crucial  to  first understand the endogenous response to cardiac tissue damage and  how  to restore immune  tolerance to  cardiac  tissue,  before  additional  regenerative therapies can achieve their full potential.
AU  - Sattler,S
AU  - Fairchild,P
AU  - Watt,F
AU  - Rosenthal,N
AU  - Harding,S
DO  - 10.1038/s41536-017-0022-3
PY  - 2017///
SN  - 2057-3995
TI  - The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?
T2  - npj Regenerative Medicine
UR  - http://dx.doi.org/10.1038/s41536-017-0022-3
UR  - http://hdl.handle.net/10044/1/48533
VL  - 2
ER  -
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