Imperial College London
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DrNadiaSoliman

Faculty of Medicine, Department of Surgery & Cancer

Research Associate
 
 
 
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Contact

 

+44 (0)20 3315 8424 ext 58424n.soliman16

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Soliman:2020:10.1097/j.pain.0000000000001974,
author = {Soliman, N and Rice, A and Vollert, J},
doi = {10.1097/j.pain.0000000000001974},
journal = {Pain},
pages = {1949--1954},
title = {A practical Guide to preclinical systematic review and meta-analysis},
url = {http://dx.doi.org/10.1097/j.pain.0000000000001974},
volume = {161},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Preclinical systematic reviews (SRs) and meta-analyses (MAs) are important research activities to address the translational challenges of pain research.  SRs provide empirical evidence to gain knowledge, inform future research agendas and grant applications concurrent to developing researchers’ professional skills.  SRs are an effective approach to consolidating high volume, rapidly accruing and often conflicting research on a specific topic.  Designed to address a specific research question, SRs use predefined methods to identify, select and critically appraise all available and relevant literature to answer that question in an unbiased manner [18].  This structured approach distinguishes SRs from narrative reviews.  Where appropriate a MA can follow, whereby quantitative data are extracted and statistical techniques are used to summarise the outputs.  Together, a SR and MA can be conducted to assess the quality of experimental design, conduct, analysis and reporting and the reliability of all available and relevant data [45].  Through decades of innovation by the Cochrane Collaboration and others, SRs and MAs now lie at the centre of clinical evidence. The information provided has fundamentally revolutionised clinical medicine at all levels from informing policy and funding decisions to determining optimal treatments for individual patients. Before a clinical research project or funding application, it is best practise to conduct a SR to ascertain what is already known and to identify knowledge gaps. In the preclinical setting SRs are relatively novel, partially because of inherent complexities and resource requirements for processing the large number and diverse preclinical publications; paradoxically a strong justification for SRs because they provide the means to synthesise evidence from heterogeneous studies.  In some fields they are gaining popularity (e.g. stroke [37]) and feasibility is improving with technical advances e.g. online review software, ma
AU  - Soliman,N
AU  - Rice,A
AU  - Vollert,J
DO  - 10.1097/j.pain.0000000000001974
EP  - 1954
PY  - 2020///
SN  - 0304-3959
SP  - 1949
TI  - A practical Guide to preclinical systematic review and meta-analysis
T2  - Pain
UR  - http://dx.doi.org/10.1097/j.pain.0000000000001974
UR  - https://journals.lww.com/pain/Fulltext/2020/09000/A_practical_guide_to_preclinical_systematic_review.4.aspx
UR  - http://hdl.handle.net/10044/1/81136
VL  - 161
ER  -
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