Imperial College London
Alternate

Professor Neil Ferguson

Faculty of Medicine, School of Public Health

Director of the School of Public Health
 
 
 
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Contact

 

+44 (0)20 7594 3296neil.ferguson Website

 
 
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Location

 

508School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clapham:2016:10.1371/journal.pcbi.1004951,
author = {Clapham, HE and Quyen, TH and Kien, DT and Dorigatti, I and Simmons, CP and Ferguson, NM},
doi = {10.1371/journal.pcbi.1004951},
journal = {PLOS Computational Biology},
title = {Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance.},
url = {http://dx.doi.org/10.1371/journal.pcbi.1004951},
volume = {12},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dengue is an infection of increasing global importance, yet uncertainty remains regarding critical aspects of its virology, immunology and epidemiology. One unanswered question is how infection is controlled and cleared during a dengue infection. Antibody is thought to play a role, but little past work has examined the kinetics of both virus and antibody during natural infections. We present data on multiple virus and antibody titres measurements recorded sequentially during infection from 53 Vietnamese dengue patients. We fit mechanistic mathematical models of the dynamics of viral replication and the host immune response to these data. These models fit the data well. The model with antibody removing virus fits the data best, but with a role suggested for ADCC or other infected cell clearance mechanisms. Our analysis therefore shows that the observed viral and antibody kinetics are consistent with antibody playing a key role in controlling viral replication. This work gives quantitative insight into the relationship between antibody levels and the efficiency of viral clearance. It will inform the future development of mechanistic models of how vaccines and antivirals might modify the course of natural dengue infection.
AU  - Clapham,HE
AU  - Quyen,TH
AU  - Kien,DT
AU  - Dorigatti,I
AU  - Simmons,CP
AU  - Ferguson,NM
DO  - 10.1371/journal.pcbi.1004951
PY  - 2016///
SN  - 1553-734X
TI  - Modelling Virus and Antibody Dynamics during Dengue Virus Infection Suggests a Role for Antibody in Virus Clearance.
T2  - PLOS Computational Biology
UR  - http://dx.doi.org/10.1371/journal.pcbi.1004951
UR  - http://hdl.handle.net/10044/1/33053
VL  - 12
ER  -
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