Imperial College London
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Professor Omar Usmani

Faculty of Medicine, National Heart & Lung Institute

Professor of Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7351 8051o.usmani

 
 
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Location

 

Asthma LabSouth BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Price:2019:10.1186/s13601-019-0282-7,
author = {Price, DB and Bosnic-Anticevich, S and Pavord, ID and Roche, N and Halpin, DMG and Bjermer, L and Usmani, OS and Brusselle, G and Ming, SWY and Rastogi, S},
doi = {10.1186/s13601-019-0282-7},
journal = {Clinical and Translational Allergy},
title = {Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations},
url = {http://dx.doi.org/10.1186/s13601-019-0282-7},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundBlood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations.MethodsThis observational study included data from the Optimum Patient Care Research Database. Asthma patients (18–80 years) with valid continuous data for 1 year before FeNO reading, ≥ 1 inhaled corticosteroid prescription, and BEC recorded ≤ 5 years before FeNO reading were separated into cohorts. Categorisation 1 was based on the American Thoracic Society criteria for elevated FeNO concentration (high: ≥ 50 ppb; non-high: < 25 ppb) and BEC (high: ≥ 0.300 × 109 cells/L; non-high: < 0.300 × 109 cells/L). Categorisation 2 (FeNO concentration, high: ≥ 35 ppb; non-high: < 35 ppb) was based on prior research. Reference groups included patients with neither biomarker raised.ResultsIn categorisation 1, patients with either high FeNO or high BEC (n = 200) had a numerically greater exacerbation rate (unadjusted rate ratio, 1.31 [95% confidence interval: 0.97, 1.76]) compared with patients in the reference group. Combination of high FeNO and high BEC (n = 27) resulted in a significantly greater exacerbation rate (3.67 [1.49, 9.04]). Similarly, for categorisation 2, when both biomarkers were raised (n = 53), a significantly greater exacerbation rate was observed (1.72 [1.00, 2.93]).ConclusionThe combination of high FeNO and high BEC was associated with significantly increased severe exacerbation rates in the year preceding FeNO reading, suggesting that combining FeNO and BEC measurements in primary care may identify asthma patients at risk of exacerb
AU  - Price,DB
AU  - Bosnic-Anticevich,S
AU  - Pavord,ID
AU  - Roche,N
AU  - Halpin,DMG
AU  - Bjermer,L
AU  - Usmani,OS
AU  - Brusselle,G
AU  - Ming,SWY
AU  - Rastogi,S
DO  - 10.1186/s13601-019-0282-7
PY  - 2019///
SN  - 2045-7022
TI  - Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations
T2  - Clinical and Translational Allergy
UR  - http://dx.doi.org/10.1186/s13601-019-0282-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000483502800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://ctajournal.biomedcentral.com/articles/10.1186/s13601-019-0282-7
UR  - http://hdl.handle.net/10044/1/87058
VL  - 9
ER  -
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