Imperial College London
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DrPaulaCunnea

Faculty of Medicine, Department of Surgery & Cancer

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 1548p.cunnea

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2022:10.3389/fimmu.2022.1049340,
author = {Yang, Y and Li, H and Fotopoulou, C and Cunnea, P and Zhao, X},
doi = {10.3389/fimmu.2022.1049340},
journal = {Frontiers in Immunology},
pages = {1--37},
title = {Toll-like receptor-targeted anti-tumor therapies: Advances and challenges},
url = {http://dx.doi.org/10.3389/fimmu.2022.1049340},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to stimulate innate immune reactions against microbial infection. TLRs also play essential roles in bridging the innate and adaptive immune system, playing multiple roles in inflammation, autoimmune diseases, and cancer. Thanks to the immune stimulatory potential of TLRs, TLR-targeted strategies in cancer treatment have proved to be able to regulate the tumor microenvironment towards tumoricidal phenotypes. Quantities of pre-clinical studies and clinical trials using TLR-targeted strategies in treating cancer have been initiated, with some drugs already becoming part of standard care. Here we review the structure, ligand, signaling pathways, and expression of TLRs; we then provide an overview of the pre-clinical studies and an updated clinical trial watch targeting each TLR in cancer treatment; and finally, we discuss the challenges and prospects of TLR-targeted therapy.
AU  - Yang,Y
AU  - Li,H
AU  - Fotopoulou,C
AU  - Cunnea,P
AU  - Zhao,X
DO  - 10.3389/fimmu.2022.1049340
EP  - 37
PY  - 2022///
SN  - 1664-3224
SP  - 1
TI  - Toll-like receptor-targeted anti-tumor therapies: Advances and challenges
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2022.1049340
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000893814400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049340/full
UR  - http://hdl.handle.net/10044/1/103742
VL  - 13
ER  -
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