Imperial College London
Alternate

Professor Sir Peter Barnes, FRS, FMedSci

Faculty of Medicine, National Heart & Lung Institute

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 7959p.j.barnes Website CV

 
 
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Assistant

 

Miss Carolyn Green +44 (0)20 7594 7959

 
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Location

 

227CGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

2499 results found

FULLER RW, MAXWELL DL, DIXON CMS, MCGREGOR GP, BARNES VF, BLOOM SR, BARNES PJet al., 1987, EFFECT OF SUBSTANCE-P ON CARDIOVASCULAR AND RESPIRATORY-FUNCTION IN SUBJECTS, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 62, Pages: 1473-1479, ISSN: 8750-7587

Journal article

EVANS TW, ROGERS DF, ROBERTS NM, CHUNG KF, BARNES PJet al., 1987, MEDIATORS OF INCREASED VASCULAR-PERMEABILITY DURING ANAPHYLAXIS IN SENSITIZED GUINEA-PIGS, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 221-221, ISSN: 0040-6376

Conference paper

CHUNG KF, BARNES PJ, 1987, BRONCHIAL HYPERREACTIVITY INDUCED BY PLATELET-ACTIVATING-FACTOR (PAF) - MODIFICATION BY A BETA-AGONIST, Publisher: BRITISH MED JOURNAL PUBL GROUP, Pages: 220-220, ISSN: 0040-6376

Conference paper

CLARKE B, TILL J, ROWLAND E, WARD DE, BARNES PJ, SHINEBOURNE EAet al., 1987, RAPID AND SAFE TERMINATION OF SUPRAVENTRICULAR TACHYCARDIA IN CHILDREN BY ADENOSINE, LANCET, Vol: 1, Pages: 299-301, ISSN: 0140-6736

Journal article

BARNES PJ, 1987, NEUROPEPTIDES IN THE LUNG - LOCALIZATION, FUNCTION, AND PATHOPHYSIOLOGIC IMPLICATIONS, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 79, Pages: 285-295, ISSN: 0091-6749

Journal article

GREENBERG B, RHODEN K, BARNES PJ, 1987, ENDOTHELIUM-DEPENDENT RELAXATION OF HUMAN PULMONARY-ARTERIES, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 252, Pages: H434-H438, ISSN: 0002-9513

Journal article

Chung KF, Dent G, McCusker M, Guinot P, Page CP, Barnes PJet al., 1987, Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man., Lancet, Vol: 1, Pages: 248-251, ISSN: 0140-6736

Antagonism of the effects of platelet activating factor (PAF) by the ginkgolide mixture BN 52063 was assessed in a double-blind, placebo-controlled, crossover study in 6 normal subjects. Weal and flare responses to 400 ng PAF, examined 2 h after ingestion of BN 52063 (80 mg, 120 mg) were inhibited in a dose-related manner. After 120 mg the flare area was reduced by a mean 62.4% (p less than 0.005) and the weal volume by a mean 60% (p less than 0.05). Both doses of BN 52063 significantly inhibited PAF-induced platelet aggregation in platelet-rich plasma (p less than 0.001). In vitro, BN 52063 inhibited PAF-induced but not ADP-induced platelet aggregation. Thus BN 52063 seems to be an antagonist of PAF in man.

Journal article

CHUNG KF, MCCUSKER M, PAGE CP, DENT G, GUINOT P, BARNES PJet al., 1987, EFFECT OF A GINKGOLIDE MIXTURE (BN-52063) IN ANTAGONIZING SKIN AND PLATELET RESPONSES TO PLATELET-ACTIVATING-FACTOR IN MAN, LANCET, Vol: 1, Pages: 248-251, ISSN: 0140-6736

Journal article

CHUNG KF, BARNES PJ, 1987, TREATMENT OF ASTHMA, BRITISH MEDICAL JOURNAL, Vol: 294, Pages: 103-105, ISSN: 0959-8138

Journal article

Greenberg B, Rhoden K, Barnes PJ, 1987, Endothelium-dependent relaxation of human pulmonary arteries, American Journal of Physiology - Heart and Circulatory Physiology, Vol: 252, ISSN: 0363-6135

Although endothelial cell (EC)-dependent relaxation has been described in most mammals, there have been no detailed reports of its existence in humans. Consequently, we evaluated human pulmonary artery segments taken from uninvolved regions of resected lung from 11 patients. EC removal did not significantly alter relaxation to vasoactive intestinal peptide (VIP). However, relaxation to acetylcholine (ACh) was observed only in segments with EC. Preincubation with either 1 μM propranolol or 10 μM indomethacin failed to block relaxation, but the addition of either 30 μM quinacrine hydrochloride or 100 μM nordihydroguaiaretic acid prevented it entirely. EC-dependent relaxation to ATP was also demonstrated. These data demonstrate that EC-dependent relaxation occurs in human pulmonary arteries. Neither β-adrenergic pathways nor prostaglandin intermediaries are utilized. An oxidized breakdown product of arachidonic or some other fatty acid from EC phospholipid appears to be involved. These data suggest that interactions between endothelium and smooth muscle may be important in modulating tone in the vessel wall and that damage to the endothelium may play a role in the development of pulmonary hypertension in humans.

Journal article

Cuss FM, Barnes PJ, 1987, Epithelial mediators, American Review of Respiratory Disease, Vol: 136, ISSN: 0003-0805

The bronchial epithelium has a number of mechanical functions including mucociliary clearance and protection against noxious agents. However, there is increasing evidence that it is a metabolically active tissue that may modulate the function of the underlying smooth muscle by metabolism and regulation of mediators and the production of relaxant, constrictor, or chemotactic factors. It is therefore possible that the epithelial abnormalities observed in asthmatics may lead, via several different mechanisms, to increased bronchial hyperresponsiveness, which is a fundamental feature of asthma. However, it may not be necessary to invoke structural damage to explain derangement of epithelial function. It is possible that functional biochemical abnormalities may be present in epithelial cells, thereby producing bronchial hyperresponsiveness in the absence of histologic abnormalities. Further studies with bronchial epithelium, similar to those with vascular endothelium, are needed to clarify its role in the pathogenesis of asthma.

Journal article

Barnes P, 1987, Theophylline preparations, Journal of the Institute of Medicine, Vol: 9, Pages: 235-238, ISSN: 0259-0972

Journal article

Grandordy BM, Barnes PJ, 1987, Phosphoinositide turnover, American Review of Respiratory Disease, Vol: 136, ISSN: 0003-0805

  • Cite
  • Citations: 19
Journal article

DIXON CMS, FULLER RW, BARNES PJ, 1987, THE EFFECT OF AN ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR, RAMIPRIL, ON BRONCHIAL RESPONSES TO INHALED HISTAMINE AND BRADYKININ IN ASTHMATIC SUBJECTS, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 23, Pages: 91-93, ISSN: 0306-5251

Journal article

BARNES PJ, 1987, AIRWAY NEUROPEPTIDES AND ASTHMA, TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 8, Pages: 24-27, ISSN: 0165-6147

Journal article

FULLER RW, DIXON CMS, CUSS FMC, BARNES PJet al., 1987, BRADYKININ-INDUCED BRONCHOCONSTRICTION IN HUMANS - MODE OF ACTION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 135, Pages: 176-180, ISSN: 0003-0805

Journal article

SMOLENSKY MH, KUNKEL G, DALONZO GE, BARNES PJet al., 1987, SPECIAL ISSUE - CIRCADIAN RHYTHM-ADAPTED THEOPHYLLINE SCHEDULES FOR ASTHMA - EDITORIAL, CHRONOBIOLOGY INTERNATIONAL, Vol: 4, Pages: 301-302, ISSN: 0742-0528

Journal article

BARNES PJ, 1987, MUSCARINIC RECEPTORS IN LUNG, POSTGRADUATE MEDICAL JOURNAL, Vol: 63, Pages: 13-19, ISSN: 0032-5473

Journal article

SMOLENSKY MH, DALONZO GE, KUNKEL G, BARNES PJet al., 1987, DAY NIGHT PATTERNS IN BRONCHIAL PATENCY AND DYSPNEA - BASIS FOR ONCE-DAILY AND UNEQUALLY DIVIDED TWICE-DAILY THEOPHYLLINE DOSING SCHEDULES, CHRONOBIOLOGY INTERNATIONAL, Vol: 4, Pages: 303-317, ISSN: 0742-0528

Journal article

Barnes PJ, 1987, Airway neuropeptides and airway disease., Ann Ital Med Int, Vol: 2, Pages: 327-332, ISSN: 0393-9340

Journal article

SMOLENSKY MH, DALONZO GE, KUNKEL G, BARNES PJet al., 1987, SUSTAINED-RELEASE THEOPHYLLINE AND NOCTURNAL ASTHMA, ONCE-DAILY AND UNEQUAL DOSING SCHEDULES - SUMMARY AND PERSPECTIVES, CHRONOBIOLOGY INTERNATIONAL, Vol: 4, Pages: 459-466, ISSN: 0742-0528

Journal article

Barnes PJ, 1987, New concepts in the pathogenesis of bronchial hyperresponsiveness., Agents Actions Suppl, Vol: 21, Pages: 225-237, ISSN: 0379-0363

Journal article

EVANS TW, DENT G, ROGERS DF, AURSUDKIJ B, CHUNG KF, BARNES PJet al., 1987, EFFECT OF A PLATELET-ACTIVATING-FACTOR (PAF) ANTAGONIST (WEB 2086) ON PAF INDUCED AIRWAY MICROVASCULAR LEAKAGE AND PLATELET-AGGREGATION, Publisher: PORTLAND PRESS, Pages: P68-P68, ISSN: 0143-5221

Conference paper

BARNES PJ, 1986, NEURAL CONTROL OF HUMAN AIRWAYS IN HEALTH AND DISEASE, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 134, Pages: 1289-1314, ISSN: 0003-0805

Journal article

PALMER JBD, CUSS FMC, BARNES PJ, 1986, VIP AND PHM AND THEIR ROLE IN NONADRENERGIC INHIBITORY RESPONSES IN ISOLATED HUMAN AIRWAYS, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 61, Pages: 1322-1328, ISSN: 8750-7587

Journal article

CARSTAIRS JR, BARNES PJ, 1986, VISUALIZATION OF VASOACTIVE-INTESTINAL-PEPTIDE RECEPTORS IN HUMAN AND GUINEA-PIG LUNG, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 239, Pages: 249-255, ISSN: 0022-3565

Journal article

COE CI, BARNES PJ, 1986, REDUCTION OF NOCTURNAL ASTHMA BY AN INHALED ANTICHOLINERGIC DRUG, CHEST, Vol: 90, Pages: 485-488, ISSN: 0012-3692

Journal article

BARNES PJ, CADIEUX A, CARSTAIRS JR, GREENBERG B, POLAK JM, RHODEN Ket al., 1986, VASOACTIVE-INTESTINAL-PEPTIDE IN BOVINE PULMONARY-ARTERY - LOCALIZATION, FUNCTION AND RECEPTOR AUTORADIOGRAPHY, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 89, Pages: 157-162, ISSN: 0007-1188

Journal article

GREENBERG B, RHODEN K, BARNES PJ, 1986, ACTIVATED OXYGEN MOLECULES GENERATED BY ELECTRICAL-STIMULATION AFFECT VASCULAR SMOOTH-MUSCLE, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 18, Pages: 975-981, ISSN: 0022-2828

Journal article

PALMER JBD, CUSS FMC, WARREN JB, BLANK M, BLOOM SR, BARNES PJet al., 1986, EFFECT OF INFUSED VASOACTIVE-INTESTINAL-PEPTIDE ON AIRWAY FUNCTION IN NORMAL SUBJECTS, THORAX, Vol: 41, Pages: 663-666, ISSN: 0040-6376

Journal article

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