Imperial College London
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ProfessorPaulKellam

Faculty of Medicine, Department of Infectious Disease

Professor of Virus Genomics
 
 
 
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Contact

 

p.kellam

 
 
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Location

 

460Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Abdullahi:2023:jac/dkad195,
author = {Abdullahi, A and Kida, IM and Maina, UA and Ibrahim, AH and Mshelia, J and Wisso, H and Adamu, A and Onyemata, JE and Edun, M and Yusuph, H and Aliyu, SH and Charurat, M and Abimiku, A and Abeler-Dorner, L and Fraser, C and Bonsall, D and PANGEA, C and Kemp, SA and Gupta, RK},
doi = {jac/dkad195},
journal = {Journal of Antimicrobial Chemotherapy},
pages = {2000--2007},
title = {Limited emergence of resistance to integrase strand transfer inhibitors (INSTIs) in ART-experienced participants failing dolutegravir-based antiretroviral therapy: a cross-sectional analysis of a Northeast Nigerian cohort},
url = {http://dx.doi.org/10.1093/jac/dkad195},
volume = {78},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundDue to the high prevalence of resistance to NNRTI-based ART since 2018, consolidated recommendations from the WHO have indicated dolutegravir as the preferred drug of choice for HIV treatment globally. There is a paucity of resistance outcome data from HIV-1 non-B subtypes circulating across West Africa.AimsWe characterized the mutational profiles of persons living with HIV from a cross-sectional cohort in North-East Nigeria failing a dolutegravir-based ART regimen.MethodsWGS of plasma samples collected from 61 HIV-1-infected participants following virological failure of dolutegravir-based ART were sequenced using the Illumina platform. Sequencing was successfully completed for samples from 55 participants. Following quality control, 33 full genomes were analysed from participants with a median age of 40 years and median time on ART of 9 years. HIV-1 subtyping was performed using SNAPPy.ResultsMost participants had mutational profiles reflective of exposure to previous first- and second-line ART regimens comprised NRTIs and NNRTIs. More than half of participants had one or more drug resistance-associated mutations (DRMs) affecting susceptibility to NRTIs (17/33; 52%) and NNRTIs (24/33; 73%). Almost a quarter of participants (8/33; 24.4%) had one or more DRMs affecting tenofovir susceptibility. Only one participant, infected with HIV-1 subtype G, had evidence of DRMs affecting dolutegravir susceptibility—this was characterized by the T66A, G118R, E138K and R263K mutations.ConclusionsThis study found a low prevalence of resistance to dolutegravir; the data are therefore supportive of the continual rollout of dolutegravir as the primary first-line regimen for ART-naive participants and the preferred switch to second-line ART across the region. However, population-level, longer-term data collection on dolutegravir outcomes are required to further guide implementation and policy action across the region.
AU  - Abdullahi,A
AU  - Kida,IM
AU  - Maina,UA
AU  - Ibrahim,AH
AU  - Mshelia,J
AU  - Wisso,H
AU  - Adamu,A
AU  - Onyemata,JE
AU  - Edun,M
AU  - Yusuph,H
AU  - Aliyu,SH
AU  - Charurat,M
AU  - Abimiku,A
AU  - Abeler-Dorner,L
AU  - Fraser,C
AU  - Bonsall,D
AU  - PANGEA,C
AU  - Kemp,SA
AU  - Gupta,RK
DO  - jac/dkad195
EP  - 2007
PY  - 2023///
SN  - 0305-7453
SP  - 2000
TI  - Limited emergence of resistance to integrase strand transfer inhibitors (INSTIs) in ART-experienced participants failing dolutegravir-based antiretroviral therapy: a cross-sectional analysis of a Northeast Nigerian cohort
T2  - Journal of Antimicrobial Chemotherapy
UR  - http://dx.doi.org/10.1093/jac/dkad195
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:001013920600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://academic.oup.com/jac/article/78/8/2000/7208628
UR  - http://hdl.handle.net/10044/1/107064
VL  - 78
ER  -
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