Imperial College London
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ProfessorPeterKohl

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

p.kohl Website

 
 
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Location

 

Heart Science CentreHarefield Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Rog-Zielinska:2016:10.1016/j.molmed.2015.12.006,
author = {Rog-Zielinska, EA and Norris, RA and Kohl, P and Markwald, R},
doi = {10.1016/j.molmed.2015.12.006},
journal = {Trends in Molecular Medicine},
pages = {99--114},
title = {The living scar - cardiac fibroblasts and the injured heart},
url = {http://dx.doi.org/10.1016/j.molmed.2015.12.006},
volume = {22},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cardiac scars, often dubbed ‘dead tissue’, are very much alive, with heterocellular activity contributing to the maintenance of structural and mechanical integrity following heart injury. To form a scar, non-myocytes such as fibroblasts are recruited from intra- and extra-cardiac sources. Fibroblasts perform important autocrine and paracrine signaling functions. They also establish mechanical and, as is increasingly evident, electrical junctions with other cells. While fibroblasts were previously thought to act simply as electrical insulators, they may be electrically connected among themselves and, under some circumstances, to other cells including cardiomyocytes. A better understanding of these biophysical interactions will help to target scar structure and function, and will facilitate the development of novel therapies aimed at modifying scar properties for patient benefit.
AU  - Rog-Zielinska,EA
AU  - Norris,RA
AU  - Kohl,P
AU  - Markwald,R
DO  - 10.1016/j.molmed.2015.12.006
EP  - 114
PY  - 2016///
SN  - 1471-4914
SP  - 99
TI  - The living scar - cardiac fibroblasts and the injured heart
T2  - Trends in Molecular Medicine
UR  - http://dx.doi.org/10.1016/j.molmed.2015.12.006
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000370091000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/43559
VL  - 22
ER  -
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