Imperial College London
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DrPascaleKropf

Faculty of Medicine, Department of Infectious Disease

Reader in Immunology
 
 
 
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Contact

 

+44 (0)20 7594 1755p.kropf

 
 
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Location

 

120Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Abebe:2012:10.1371/journal.pntd.0001684,
author = {Abebe, T and Hailu, A and Woldeyes, M and Mekonen, W and Bilcha, K and Cloke, T and Fry, L and al, Basatena N-KS and Corware, K and Modolell, M and Munder, M and Tacchini-Cottier, F and Mueller, I and Kropf, P},
doi = {10.1371/journal.pntd.0001684},
journal = {PLOS Neglected Tropical Diseases},
title = {Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia},
url = {http://dx.doi.org/10.1371/journal.pntd.0001684},
volume = {6},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundCutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity. Persistent nonhealing cutaneous leishmaniasis has been associated with poor T cell mediated responses; however, the underlying mechanisms are not well understood.Methodology/Principal FindingsWe have recently shown in an experimental model of cutaneous leishmaniasis that arginase-induced L-arginine metabolism suppresses antigen-specific T cell responses at the site of pathology, but not in the periphery. To test whether these results translate to human disease, we recruited patients presenting with localized lesions of cutaneous leishmaniasis and assessed the levels of arginase activity in cells isolated from peripheral blood and from skin biopsies. Arginase activity was similar in peripheral blood mononuclear cells (PBMCs) from patients and healthy controls. In sharp contrast, arginase activity was significantly increased in lesion biopsies of patients with localized cutaneous leishmaniasis as compared with controls. Furthermore, we found that the expression levels of CD3ζ, CD4 and CD8 molecules were considerably lower at the site of pathology as compared to those observed in paired PBMCs.ConclusionOur results suggest that increased arginase in lesions of patients with cutaneous leishmaniasis might play a role in the pathogenesis of the disease by impairing T cell effector functions.
AU  - Abebe,T
AU  - Hailu,A
AU  - Woldeyes,M
AU  - Mekonen,W
AU  - Bilcha,K
AU  - Cloke,T
AU  - Fry,L
AU  - al,Basatena N-KS
AU  - Corware,K
AU  - Modolell,M
AU  - Munder,M
AU  - Tacchini-Cottier,F
AU  - Mueller,I
AU  - Kropf,P
DO  - 10.1371/journal.pntd.0001684
PY  - 2012///
SN  - 1935-2735
TI  - Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia
T2  - PLOS Neglected Tropical Diseases
UR  - http://dx.doi.org/10.1371/journal.pntd.0001684
UR  - http://hdl.handle.net/10044/1/32211
VL  - 6
ER  -
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