Imperial College London
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DrPanteleimonTakis

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Associate
 
 
 
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Contact

 

p.takis Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Norris:2022:10.1136/heartjnl-2021-320047,
author = {Norris, T and Razieh, C and Zaccardi, F and Yates, T and Islam, N and Gillies, CL and Chudasama, Y and Rowlands, A and Davies, MJ and McCann, GP and Banerjee, A and Lam, CSP and Docherty, AB and Openshaw, PJM and Baillie, JK and Semple, MG and Lawson, CA and Khunti, K},
doi = {10.1136/heartjnl-2021-320047},
journal = {Heart},
pages = {1200--1208},
title = {Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19},
url = {http://dx.doi.org/10.1136/heartjnl-2021-320047},
volume = {108},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective Using a large national database of people hospitalised with COVID-19, we investigated the contribution of cardio-metabolic conditions, multi-morbidity and ethnicity on the risk of in-hospital cardiovascular complications and death.Methods A multicentre, prospective cohort study in 302 UK healthcare facilities of adults hospitalised with COVID-19 between 6 February 2020 and 16 March 2021. Logistic models were used to explore associations between baseline patient ethnicity, cardiometabolic conditions and multimorbidity (0, 1, 2, >2 conditions), and in-hospital cardiovascular complications (heart failure, arrhythmia, cardiac ischaemia, cardiac arrest, coagulation complications, stroke), renal injury and death.Results Of 65 624 patients hospitalised with COVID-19, 44 598 (68.0%) reported at least one cardiometabolic condition on admission. Cardiovascular/renal complications or death occurred in 24 609 (38.0%) patients. Baseline cardiometabolic conditions were independently associated with increased odds of in-hospital complications and this risk increased in the presence of cardiometabolic multimorbidity. For example, compared with having no cardiometabolic conditions, 1, 2 or ≥3 conditions was associated with 1.46 (95% CI 1.39 to 1.54), 2.04 (95% CI 1.93 to 2.15) and 3.10 (95% CI 2.92 to 3.29) times higher odds of any cardiovascular/renal complication, respectively. A similar pattern was observed for all-cause death. Compared with the white group, the South Asian (OR 1.19, 95% CI 1.10 to 1.29) and black (OR 1.53 to 95% CI 1.37 to 1.72) ethnic groups had higher risk of any cardiovascular/renal complication.Conclusions In hospitalised patients with COVID-19, cardiovascular complications or death impacts just under half of all patients, with the highest risk in those of South Asian or Black ethnicity and in patients with cardiometabolic multimorbidity.
AU  - Norris,T
AU  - Razieh,C
AU  - Zaccardi,F
AU  - Yates,T
AU  - Islam,N
AU  - Gillies,CL
AU  - Chudasama,Y
AU  - Rowlands,A
AU  - Davies,MJ
AU  - McCann,GP
AU  - Banerjee,A
AU  - Lam,CSP
AU  - Docherty,AB
AU  - Openshaw,PJM
AU  - Baillie,JK
AU  - Semple,MG
AU  - Lawson,CA
AU  - Khunti,K
DO  - 10.1136/heartjnl-2021-320047
EP  - 1208
PY  - 2022///
SN  - 1355-6037
SP  - 1200
TI  - Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
T2  - Heart
UR  - http://dx.doi.org/10.1136/heartjnl-2021-320047
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000731094800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://heart.bmj.com/content/early/2021/12/14/heartjnl-2021-320047
UR  - http://hdl.handle.net/10044/1/94897
VL  - 108
ER  -
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