Imperial College London
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DrPhilippThomas

Faculty of Natural Sciences, Department of Mathematics

Senior Lecturer in Biomathematics
 
 
 
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Contact

 

+44 (0)20 7594 2647p.thomas

 
 
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Location

 

626Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Thomas:2011:10.1063/1.3661156,
author = {Thomas, P and Straube, AV and Grima, R},
doi = {10.1063/1.3661156},
journal = {Journal of Chemical Physics},
title = {Communication: Limitations of the stochastic quasi-steady-state approximation in open biochemical reaction networks},
url = {http://dx.doi.org/10.1063/1.3661156},
volume = {135},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It is commonly believed that, whenever timescale separation holds, the predictions of reduced chemical master equations obtained using the stochastic quasi-steady-state approximation are in very good agreement with the predictions of the full master equations. We use the linear noise approximation to obtain a simple formula for the relative error between the predictions of the two master equations for the Michaelis-Menten reaction with substrate input. The reduced approach is predicted to overestimate the variance of the substrate concentration fluctuations by as much as 30%. The theoretical results are validated by stochastic simulations using experimental parameter values for enzymes involved in proteolysis, gluconeogenesis, and fermentation.
AU  - Thomas,P
AU  - Straube,AV
AU  - Grima,R
DO  - 10.1063/1.3661156
PY  - 2011///
SN  - 1089-7690
TI  - Communication: Limitations of the stochastic quasi-steady-state approximation in open biochemical reaction networks
T2  - Journal of Chemical Physics
UR  - http://dx.doi.org/10.1063/1.3661156
UR  - http://hdl.handle.net/10044/1/40994
VL  - 135
ER  -
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