Imperial College London
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DrRashedaChowdhury

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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Contact

 

r.chowdhury

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ntagiantas:2024:10.1016/j.bspc.2023.105746,
author = {Ntagiantas, K and Pignatelli, E and Peters, NS and Cantwell, CD and Chowdhury, RA and Bharath, AA},
doi = {10.1016/j.bspc.2023.105746},
journal = {Biomedical Signal Processing and Control},
title = {Estimation of fibre architecture and scar in myocardial tissue using electrograms: An in-silico study},
url = {http://dx.doi.org/10.1016/j.bspc.2023.105746},
volume = {89},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Atrial Fibrillation (AF) is characterized by disorganized electrical activity in the atria and is known to be sustained by the presence of regions of fibrosis (scars) or functional cellular remodelling, both of which may lead to areas of slow conduction. Estimating the effective conductivity of the myocardium and identifying regions of abnormal propagation is therefore crucial for the effective treatment of AF. We hypothesize that the spatial distribution of tissue conductivity can be directly inferred from an array of concurrently acquired contact electrograms (EGMs). We generate a dataset of simulated cardiac AP propagation using randomized scar distributions and a phenomenological cardiac model and calculate contact EGMs at various positions on the field. EGMs are enriched with noise extracted from biological data acquired in the lab. A deep neural network, based on a modified U-net architecture, is trained to estimate the location of the scar and quantify conductivity of the tissue with a Jaccard index of 91%. We adapt a wavelet-based surrogate testing analysis to confirm that the inferred conductivity distribution is an accurate representation of the ground truth input to the model. We find that the root mean square error (RMSE) between the ground truth and our predictions is significantly smaller (pval<0.01) than the RMSE between the ground truth and surrogate samples.
AU  - Ntagiantas,K
AU  - Pignatelli,E
AU  - Peters,NS
AU  - Cantwell,CD
AU  - Chowdhury,RA
AU  - Bharath,AA
DO  - 10.1016/j.bspc.2023.105746
PY  - 2024///
SN  - 1746-8094
TI  - Estimation of fibre architecture and scar in myocardial tissue using electrograms: An in-silico study
T2  - Biomedical Signal Processing and Control
UR  - http://dx.doi.org/10.1016/j.bspc.2023.105746
VL  - 89
ER  -
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