Imperial College London
Alternate

Professor C. Ross Ethier

Faculty of Engineering, Department of Bioengineering

Visiting Professor
 
 
 
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Contact

 

r.ethier

 
 
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Location

 

Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

427 results found

Leask RL, Butany J, Johnston KW, Ethier CR, Ojha Met al., 2005, Human saphenous vein coronary artery bypass graft morphology, geometry and hemodynamics, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 33, Pages: 301-309, ISSN: 0090-6964

Journal article

Clark AF, Brotchie D, Read AT, Hellberg P, English-Wright S, Pang IH, Ethier CR, Grierson Iet al., 2005, Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue, CELL MOTILITY AND THE CYTOSKELETON, Vol: 60, Pages: 83-95, ISSN: 0886-1544

Journal article

Sigal IA, Flanagan JG, Tertinegg I, Ethier CRet al., 2005, Reconstruction of human optic nerve heads for finite element modeling., Technol Health Care, Vol: 13, Pages: 313-329, ISSN: 0928-7329

PURPOSE: Glaucoma is a common ocular disease whose pathogenesis is hypothesized to involve biomechanical damage to optic nerve tissues. Here we describe a method for the construction of patient-specific models that can be used to evaluate the biomechanical environment within the optic nerve head. We validate the method using a virtual eye, and demonstrate its use in computing optic nerve head biomechanics. METHODS: Human eyes were imaged and the optic nerve head region was processed to allow serial plastic histologic sections to be cut. These sections were photographed, unwarped and aligned so as to reconstruct three-dimensional patient-specific models incorporating sclera, pre- and post-laminar nerve, lamina cribrosa, and pia mater. Deformations, stresses and strains were computed in the resulting model using finite element techniques. RESULTS: The approach successfully reconstructed patient-specific optic nerve head models. Reconstruction of a virtual eye showed excellent agreement between the true and reconstructed geometries, and between the deformations and strains computed on the true and reconstructed geometries. A sample reconstruction showed reasonable agreement between computed and measured retinal surface deformations. CONCLUSION: The technique presented here is viable and can be used to accurately compute human optic nerve head biomechanics.

Journal article

Sigal IA, Flanagan JG, Ethier CR, 2005, Identification of the main factors influencing optic nerve head biomechanics, Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Juzkiw T, Chan D, Dai W, Ethier CRet al., 2005, Direct measurements of human trabecular meshwork cell stiffness, Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Ethier CR, Sigal IA, Flanagan JG, 2005, Effect of scleral properties on optic nerve head (ONH) biomechanics, Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Sigal IA, Flanagan JG, Tertinegg I, Ethier CRet al., 2004, Finite element modeling of optic nerve head biomechanics, Pages: 4378-4387, ISSN: 0146-0404

PURPOSE. Biomechanical factors have been implicated in the development of glaucomatous optic neuropathy, particularly at the level of the lamina cribrosa. The goal of this study was to characterize the biomechanics of the optic nerve head using computer modeling techniques. METHODS. Several models of the optic nerve head tissues (pre- and postlaminar neural tissue, lamina cribrosa, central retinal vessel, sclera, and pia mater) were constructed. Stresses, deformations, and strains were computed using finite element modeling for a range of normal and elevated intraocular pressures. Computed retinal surface deformations were compared with measured deformation patterns in enucleated human eyes. A sensitivity analysis was performed in which tissue properties and selected geometric features were varied. RESULTS. Acute IOP-induced deformation of the vitreoretinal interface was highly dependent on optic cup shape but showed a characteristic "W-shaped" profile that did not match the deformation of the anterior surface of the lamina cribrosa. The central retinal vasculature had surprisingly little effect on optic nerve head biomechanics. At an IOP of 50 mm Hg, strains (fractional elongation) in the lamina cribrosa averaged 4% to 5.5%, dependent on model geometry, with maximum strains up to 7.7%. Strains in the lamina cribrosa were more dependent on scleral stiffness, scleral thickness, and scleral canal diameter than on lamina cribrosa stiffness and optic cup shape. CONCLUSIONS. Computed levels of strain in the lamina cribrosa are biologically significant and capable of contributing to the development of glaucomatous optic neuropathy, even without considering the probable accentuating effect of the lamina cribrosa's microarchitecture. Depending on optic cup shape, IOP-induced deformation of the vitreoretinal interface may not match lamina cribrosa deformation. This finding implies that scanning laser tomography has limited ability to estimate lamina cribrosa deform

Conference paper

Joshi AK, Leask RL, Myers JG, Ojha M, Butany J, Ethier CRet al., 2004, Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 24, Pages: 2408-2413, ISSN: 1079-5642

Journal article

Sigal IA, Flanagan JG, Tertinegg I, Ethier CRet al., 2004, Finite element modeling of optic nerve head biomechanics, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 45, Pages: 4378-4387, ISSN: 0146-0404

Journal article

Ethier CR, Read AT, Chan D, 2004, Biomechanics of Schlemm's canal endothelial cells: Influence on F-actin architecture, BIOPHYSICAL JOURNAL, Vol: 87, Pages: 2828-2837, ISSN: 0006-3495

Journal article

Ethier CR, 2004, Eye to eye, MECHANICAL ENGINEERING, Vol: 126, Pages: 8-8, ISSN: 0025-6501

Journal article

Ethier CR, Wada SG, Cban D, Stamer WDet al., 2004, Experimental and numerical studies of adenovirus delivery to outflow tissues of perfused human anterior segments, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 45, Pages: 1863-1870, ISSN: 0146-0404

Journal article

Ethier CR, Read AT, Chan DWH, 2004, Shear stress effects on Schlemm's canal endothelial cells, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U563-U563, ISSN: 0146-0404

Conference paper

Sigal IA, Flanagan JG, Tertinegg I, Ethier CRet al., 2004, Individual-specific finite element modelling of human optic nerve head biomechanics, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U665-U665, ISSN: 0146-0404

Conference paper

Read AT, Chan DWH, Ethier CR, 2004, Structural changes following latrunculin-B perfusion in human eyes, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U773-U773, ISSN: 0146-0404

Conference paper

Evans AL, Ethier CR, Read AT, Johnson Met al., 2004, Distribution of the pores in the inner wall of Schlemm's canal, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U563-U563, ISSN: 0146-0404

Conference paper

Gottanka J, Chan D, Eichhorn M, Hütjen-Drecoll E, Ethier CRet al., 2004, Effects of TGF-β2 in perfused human eyes, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 45, Pages: 153-158, ISSN: 0146-0404

Journal article

Ethier CR, Johnson M, Ruberti J, 2004, Ocular biomechanics and biotransport, ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, Vol: 6, Pages: 249-273, ISSN: 1523-9829

Journal article

Zeng DH, Ethier CR, 2003, A mesh-updating scheme for hemodynamic simulations in vessels undergoing large deformations, JOURNAL OF ENGINEERING MATHEMATICS, Vol: 47, Pages: 405-418, ISSN: 0022-0833

Journal article

Stamer WD, Chan DWH, Read AT, Ethier CRet al., 2003, Efficiency of adenoviral gene transfer to outflow cells in perfused human anterior segments, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U312-U312, ISSN: 0146-0404

Conference paper

Gottanka J, Ethier CR, Chan D, Lutjen-Drecoll Eet al., 2003, Effects of TGF-β2 on outflow facility and trabecular meshwork morphology in human eyes, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U309-U309, ISSN: 0146-0404

Conference paper

Goldwich A, Ethier CR, Chan DWH, Tamm ERet al., 2003, Perfusion with the olfactomedin domain of myocilin does not affect outflow facility, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 44, Pages: 1953-1961, ISSN: 0146-0404

Journal article

Read AT, Brotchie D, Hellberg P, Pang LH, Grierson I, Ethier CR, Clark AFet al., 2003, Discovery of cross-linked actin networks (CLANs) in outflow tissues from dexamethasone-treated human eyes, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U309-U309, ISSN: 0146-0404

Conference paper

Steinman DA, Vorp DA, Ethier CR, 2003, Computational modeling of arterial biomechanics: Insights into pathogenesis and treatment of vascular disease, JOURNAL OF VASCULAR SURGERY, Vol: 37, Pages: 1118-1128, ISSN: 0741-5214

Journal article

Ethier CR, Sigal IA, Tertinegg I, Flanagan JGet al., 2003, Optic nerve head (ONH) deformation and biomechanics studied by finite element modeling, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U295-U295, ISSN: 0146-0404

Conference paper

Zeng DH, Ding ZH, Friedman MH, Ethier CRet al., 2003, Effects of cardiac motion on right coronary artery hemodynamics, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 31, Pages: 420-429, ISSN: 0090-6964

Journal article

Bonert M, Leask RL, Butany J, Ethier CR, Myers JG, Johnston KW, Ojha Met al., 2003, The relationship between wall shear stress distributions and intimal thickening in the human abdominal aorta, BIOMEDICAL ENGINEERING ONLINE, Vol: 2

Journal article

Sigal IA, Flanagan JG, Tertinegg I, Ethier CRet al., 2003, Investigation of the biomechanical environment within the optic nerve head by finite element modelling, 2nd MIT Conference on Computational Fluid and Solid Mechanics, Publisher: ELSEVIER SCIENCE BV, Pages: 1810-1813

Conference paper

Kaazempur-Mofrad MR, Minev PD, Ethier CR, 2003, A characteristic/finite element algorithm for time-dependent 3-D advection-dominated transport using unstructured grids, COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, Vol: 192, Pages: 1281-1298, ISSN: 0045-7825

Journal article

Kaazempur-Mofrad MR, Ethier CR, 2002, An efficient characteristics Galerkin scheme for the advection equation in 3-D, Computer Methods in Applied Mechanics and Engineering, Vol: 191, Pages: 5345-5363, ISSN: 0045-7825

Conventional Galerkin-based finite element algorithms perform poorly when modeling advective transport. Here we develop and test a characteristic Galerkin scheme to solve the unsteady three-dimensional advective transport equation. ? algorithm uses tracking of the Gaussian quadrature points to project the information from the Eulerian background grid to the Lagrangian grid. Numerical experiments were carried out to investigate the performance of this ?. Despite speculations to the contrary in the literature, this scheme does not suffer from instability problems. ?, it is conservative, and shows good phase characteristics with slight numerical diffusion. We conclude that the characteristic Galerkin method is a viable and efficient scheme for solving advection problems in three dimensions. © 2002 Elsevier Science B.V. All rights reserved.

Journal article

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