Publications
427 results found
Johnson M, Chan D, Read AT, et al., 2002, The pore density in the inner wall endothelium of Schlemm's canal of glaucomatous eyes, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 43, Pages: 2950-2955, ISSN: 0146-0404
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- Citations: 91
Stangeby DK, Ethier CR, 2002, Coupled computational analysis of arterial LDL transport -- effects of hypertension., Comput Methods Biomech Biomed Engin, Vol: 5, Pages: 233-241, ISSN: 1025-5842
Hypertension, a risk factor for atherosclerosis, increases the uptake of low density lipoproteins (LDL) by the arterial wall. Our objective in this work was to use computational modeling to identify physical factors that could be partially responsible for this effect. Fluid flow and mass transfer patterns in the lumen and wall of an arterial model were computed in a coupled manner, replicating as closely as possible previous experimental studies in which LDL uptake into the artery wall was measured in straight, excised arterial segments. Under conditions of both flow and no-flow, simulations predicted an increase in concentration polarization of LDL at the artery wall when arterial pressure was increased from 120 to 160 mmHg. However, this led to only a slight increase in mean LDL concentration within the arterial wall. However, if the permeability of the endothelium to LDL was allowed to vary with intra-arterial pressure, then the simulations predicted that the uptake of LDL would be enhanced 1.9-2.6 fold at higher pressure. The magnitude of this increase was consistent with experimental data. We conclude that the concentration polarization effects, enhanced by elevated intra-arterial pressure, cannot explain the increase in LDL uptake seen under hypertensive conditions. Instead, the data are most consistent with a pressure-linked increase in endothelial permeability to LDL.
Johnson M, Chan D, Reed AT, et al., 2002, Glaucomatous eyes have a reduced pore density in the inner wall endothelium of Schlemm's canal, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U1137-U1137, ISSN: 0146-0404
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- Citations: 2
Bonert M, Myers JG, Fremes S, et al., 2002, A numerical study of blood flow in coronary artery bypass graft side-to-side anastomoses, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 30, Pages: 599-611, ISSN: 0090-6964
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- Citations: 50
Goldwich A, Ethier CR, Tamm ER, 2002, Perfusion with the olfactomedin domain of myocilin does not show major effects on outflow facility in anterior eye segment organ cultures, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U228-U228, ISSN: 0146-0404
Ethier CR, 2002, Computational Modeling of mass transfer and links to atherosclerosis, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 30, Pages: 461-471, ISSN: 0090-6964
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- Citations: 101
Ethier CR, 2002, The inner wall of Schlemm's canal, EXPERIMENTAL EYE RESEARCH, Vol: 74, Pages: 161-172, ISSN: 0014-4835
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- Citations: 98
Stangeby DK, Ethier CR, 2002, Computational analysis of coupled blood-wall arterial LDL transport, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 124, Pages: 1-8, ISSN: 0148-0731
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- Citations: 96
Zhang W, Ethier CR, 2002, Method for non-invasive concentration measurement in polymer mixtures: Tests with dextran and cytochrome-c, CHEMICAL ENGINEERING COMMUNICATIONS, Vol: 189, Pages: 101-113, ISSN: 0098-6445
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- Citations: 3
Kaazempur-Mofrad MR, Ethier CR, 2002, An efficient characteristic Galerkin scheme for the advection equation in 3-D, COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, Vol: 191, Pages: 5345-5363, ISSN: 0045-7825
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- Citations: 21
Ethier CR, Liu H, Tertinegg I, et al., 2001, Individual-specific modelling of lamina cribrosa biomechanics, Pages: 697-698, ISSN: 1071-6947
A method to study the biomechanics of the lamina cribrosa (LC) that utilized individual-specific anatomical features was presented. The variations in LC tissue density with the pressure-induced deformation of the overlying anterior optic nerve head (ONH) surface were correlated. The study used paired human eyes obtained within 24 hours post mortem which were surgically prepared.
Ethier CR, 2001, Bioengineering and biophysics, COMPUTING IN SCIENCE & ENGINEERING, Vol: 3, Pages: 38-39, ISSN: 1521-9615
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- Citations: 1
Ethier CR, Chan DWH, 2001, Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not, Pages: 1795-1802, ISSN: 0146-0404
Purpose. To determine the effect of charged moieties within the outflow pathway on aqueous outflow facility in human eyes. Methods. After baseline facility measurement in human eye bank eyes (n = 10 pairs), one eye of each pair received anterior chamber exchange and continued perfusion with medium containing 10 mg/ml cationic ferritin. Contralateral eyes were treated in a similar manner with anionic ferritin (10.0 or 102 mg/ml). Eyes were fixed by anterior chamber exchange and perfusion with universal fixative at 8 mm Hg (corresponding to a physiologic pressure of 15 mm Hg in vivo) and examined by transmission electron microscopy. In a second series of human eyes (n = 8 pairs), facility was measured before and after anterior chamber exchange, with a solution containing 0.1 U/ml neuraminidase. Results. Perfusion of eyes with anionic ferritin at either 10.0 or 102 mg/ml caused a negligible 2% increase in facility, whereas cationic ferritin perfusion reduced facility by 66% (P < 0.00001). Perfusion with fixative reduced facility by approximately 60% in both cationic and anionic ferritin-perfused eyes, relative to facilities after perfusion with ferritin. Transmission electron microscopy showed that the distribution of ferritin was segmentally variable. Cationic ferritin consistently labeled the luminal surface of the inner wall of Schlemm's canal, and variably labeled the juxtacanalicular connective tissue (JCT) and trabecular beam surfaces. Anionic ferritin was more prominent in the JCT and intertrabecular spaces and less so on the luminal surface of Schlemm's canal. By scanning electron microscopy, cationic ferritin was seen to accumulate at intercellular margins of the inner wall. Neuraminidase perfusion had no significant effect on outflow facility. Conclusion. Cationic ferritin reduces outflow facility, presumably by binding to negatively charged sites in the outflow pathway. A possible mechanism is partial or complete blockage of intercellular clefts in the in
Ethier CR, Chan DWH, 2001, Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 42, Pages: 1795-1802, ISSN: 0146-0404
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- Citations: 69
Zhang W, Ethier CR, 2001, Direct pressure measurements in a hyaluronan ultrafiltration concentration polarization layer, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Vol: 180, Pages: 63-73, ISSN: 0927-7757
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- Citations: 12
Prakash S, Ethier CR, 2001, Requirements for mesh resolution in 3D computational hemodynamics, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 123, Pages: 134-144, ISSN: 0148-0731
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- Citations: 103
Ethier CR, Chan D, Read T, 2001, Actin distribution in JCT and inner wall of Schlemms canal., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 42, Pages: S730-S730, ISSN: 0146-0404
Flanagan JG, Liu H, Yan DB, et al., 2001, Influence of lamina cribrosa tissue density on optic nerve head biomechanics., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 42, Pages: S510-S510, ISSN: 0146-0404
Kaazempur-Mofrad MR, Ethier CR, 2001, Mass transport in an anatomically realistic human right coronary artery, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 29, Pages: 121-127, ISSN: 0090-6964
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- Citations: 68
Myers JG, Moore JA, Ojha M, et al., 2001, Factors influencing blood flow patterns in the human right coronary artery, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 29, Pages: 109-120, ISSN: 0090-6964
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- Citations: 190
Vorp DA, Steinman DA, Ethier CR, 2001, Computational modeling of arterial biomechanics, COMPUTING IN SCIENCE & ENGINEERING, Vol: 3, Pages: 51-64, ISSN: 1521-9615
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- Citations: 26
Prakash S, Ethier CR, 2001, Enhanced error estimator for adaptive finite element analysis of 3D incompressible flow, COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, Vol: 190, Pages: 5413-5426, ISSN: 0045-7825
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- Citations: 6
Myers JG, Ojha M, Wayne Johnston K, et al., 2000, Branch flow effects in the human right coronary artery trunk, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, Vol: 48, Pages: 269-270, ISSN: 1071-6947
Kaazempur-Mofrad MR, Myers JG, Ethier CR, 2000, Blood flow and transport in axisymmetric and asymmetric stenoses, Annals of Biomedical Engineering, Vol: 28, ISSN: 0090-6964
In this work we numerically study flow and the advection-dominated transport of small blood-borne components (such as oxygen and ATP) in two arterial models. The first model contained a mild (56% area reduction) axisymmetric stenosis, while the second contained the same grade of asymmetric stenosis. Using a Reynolds number of 250 (based on inlet diameter), the axisymmetric stenosis exhibited unidirectional flow, with no visible regions of separation. Conversely, the asymmetric stenosis exhibited a complex helical separation region that included a secondary swirling motion. For mass transfer simulations run at a Schmidt number of 3000, these complex secondary flows locally disturbed the concentration patterns and promoted mixing downstreams of the asymmetric stenosis.
Ethier R, Liu H, Yan D, et al., 2000, Correlation between lamina cribrosa deformation and tissue density, Annals of Biomedical Engineering, Vol: 28, ISSN: 0090-6964
Local intraocular pressure (IOP)-induced deformation of the anterior retinal surface, as well as the connective tissue density in the underlying lamina cribosa, were measured. Connective tissue densities were obtained at selected locations throughout the LC and were normalized by image intensity from the adjacent sclera. Correlations between the local deformation and LC tissue density were determined.
Bonert M, Myers JG, Fremes SE, et al., 2000, Influence of graft/host diameter ratio on the hemodynamics in sequential ita anastomoses, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, Vol: 48, Pages: 265-266, ISSN: 1071-6947
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- Citations: 4
Ethier CR, Prakash S, Steinman DA, et al., 2000, Steady flow separation patterns in a 45 degree junction, JOURNAL OF FLUID MECHANICS, Vol: 411, Pages: 1-38, ISSN: 0022-1120
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- Citations: 85
Trope GE, Flanagan JG, Tertinegg I, et al., 2000, A new method for studying lamina cribrosa behaviour in human eyes., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 41, Pages: S950-S950, ISSN: 0146-0404
Ethier CR, Tamm ER, Chan D, et al., 2000, Effects of TGF-β2 on outflow facility., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 41, Pages: S763-S763, ISSN: 0146-0404
Flanagan JG, Hutchings N, Liu H, et al., 2000, A new method to monitor glaucomatous progression: Canny edge detection of scanning laser tomography (SLT) images of the optic nerve head (ONH), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 41, Pages: S121-S121, ISSN: 0146-0404
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