Imperial College London
Alternate

Professor C. Ross Ethier

Faculty of Engineering, Department of Bioengineering

Visiting Professor
 
 
 
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Contact

 

r.ethier

 
 
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Location

 

Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

427 results found

Moore JA, Steinman DA, Karlik SJ, Rutt BK, Holdsworth D, Ethier CRet al., 1997, Computational blood flow modelling in real arteries: In vivo MRI models vs. vascular casts, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, Vol: 35, Pages: 345-346, ISSN: 1071-6947

Journal article

Moore JA, Ethier CR, 1997, Oxygen mass transfer calculations in large arteries, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 119, Pages: 469-475, ISSN: 0148-0731

Journal article

Sit AJ, Coloma FM, Ethier CR, Johnson Met al., 1997, Factors affecting the pores of the inner wall endothelium of Schlemm's canal, Pages: 1517-1525, ISSN: 0146-0404

Purpose. A linear relationship between the density of pores in the inner wall of Schlemm's canal and aqueous outflow facility has been reported previously in a study in which investigators examined only eyes fixed at constant pressure, so that fixative flow rates differed from eye to eye. Because pores may form as a function of flow rate, the purpose in the current study was to verify the previous findings, using constant flow perfusions. Methods. Outflow facility was measured in enucleated human eyes. Eyes were fixed under either constant flow or constant pressure conditions, microdissected to expose the inner wall of Schlemm's canal, and prepared for scanning electron microscopy. The density and diameter of pores in the inner wall were measured. Results. Statistical analysis showed no correlation between outflow facility and either the density or the diameter of pores. Pore density decreased significantly during the hours after death. Examining only eyes for which experimentation was started within 20 hours of death, we found that pore density increased significantly with the volume of fixative that had been perfused through the outflow pathway. Conclusions. The correlation found by Allingham et al between outflow facility and pore density in the inner wall endothelium was not confirmed. However, the relationship between pore density and volume of fixative perfused is consistent with and may be responsible for the finding in the previous study. Because fixation conditions can influence the apparent pore density in the inner wall endothelium significantly, the conclusion reached previously, that pores contribute only 10% of the aqueous outflow resistance, may require reevaluation.

Conference paper

Gowman LM, Ethier CR, 1997, Concentration and concentration gradient measurements in an ultrafiltration concentration polarization layer .2. Application to hyaluronan, JOURNAL OF MEMBRANE SCIENCE, Vol: 131, Pages: 107-123, ISSN: 0376-7388

Journal article

Gowman LM, Ethier CR, 1997, Concentration and concentration gradient measurements in an ultrafiltration concentration polarization layer .1. A laser-based refractometric experimental technique, JOURNAL OF MEMBRANE SCIENCE, Vol: 131, Pages: 95-105, ISSN: 0376-7388

Journal article

Sit AJ, Coloma FM, Ethier CR, Johnson Met al., 1997, Factors affecting the pores of the inner wall endothelium of Schlemm's canal, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 38, Pages: 1517-1525, ISSN: 0146-0404

Journal article

Yan DB, Flanagan JG, Trope GE, Ethier CRet al., 1997, An ex vivo study of regional optic nerve head deformation using scanning laser tomography, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 38, Pages: 3860-3860, ISSN: 0146-0404

Journal article

Johnson M, Sit AJ, Coloma FM, Ethier CRet al., 1997, Two populations of pores of the inner wall endothelium of Schlemm's canal, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 38, Pages: 2118-2118, ISSN: 0146-0404

Journal article

Steinman DA, Ethier CR, Rutt BK, 1997, Combined analysis of spatial and velocity displacement artifacts in phase contrast measurements of complex flows, Pages: 339-346, ISSN: 1053-1807

MR phase contrast (PC) velocity imaging is a promising tool for quantifying blood flow velocity in vivo. PC velocity imaging is, however, susceptible to artifacts that result from the displacement of spins during the finite duration pulse sequences. Such displacement artifacts can lead to errors in velocity measurements, especially in the presence of oblique and accelerating flows, which are common throughout the cardiovascular system. By tracking particles (representing spins) through a computed velocity field, and assuming that spatial and velocity encodings occur at discrete times during the pulse sequence, we simulate the separate and combined effects of oblique and acceleration artifacts on PC velocity images. We demonstrate, both by simulation and MR measurement, the errors associated with such artifacts in PC velocity measurements in a representative flow geometry. Using example particle trajectories, we provide a fluid dynamic basis for characteristic phase-velocity image distortions that can arise when imaging complex, physiologically relevant flows.

Conference paper

Moore JA, Ethier CR, Kaazempur-Mofrad M, 1996, Oxygen mass transfer in a stenosis: Effects of blood-wall coupling, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, Vol: 33, Pages: 291-292, ISSN: 1071-6947

Journal article

Barry SI, Gowman LM, Ethier CR, 1996, Obtaining the concentration-dependent diffusion coefficient from ultrafiltration experiments: Application to hyaluronate, BIOPOLYMERS, Vol: 39, Pages: 1-11, ISSN: 0006-3525

Journal article

Kunov MJ, Steinman DA, Ethier CR, 1996, Particle volumetric residence time calculations in arterial geometries, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 118, Pages: 158-164, ISSN: 0148-0731

Journal article

Steinman DA, Frayne R, Zhang XD, Rutt BK, Ethier CRet al., 1996, MR measurement and numerical simulation of steady flow in an end-to-side anastomosis model, JOURNAL OF BIOMECHANICS, Vol: 29, Pages: 537-542, ISSN: 0021-9290

Journal article

Ethier CR, Coloma FM, 1996, Inner wall pore classification and aqueous outflow, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 37, Pages: 3798-3798, ISSN: 0146-0404

Journal article

Coloma FM, Croft MA, Ethier CR, Gangnon R, Ladd B, Kaufman PLet al., 1996, Study of ECA effects on inner wall pores in living monkeys, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 37, Pages: 3796-3796, ISSN: 0146-0404

Journal article

Yan DB, Flanagan JG, Ethier CR, Farra T, Trope GEet al., 1996, Deformation of the optic nerve, head by elevated IOP - A quantitative analysis using scanning laser tomography, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 37, Pages: 3056-3056, ISSN: 0146-0404

Journal article

Ackerman JD, Cottrell CM, Ethier CR, Allen DG, Spelt JKet al., 1996, Attachment strength of zebra mussels on natural, polymeric, and metallic materials, JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE, Vol: 122, Pages: 141-148, ISSN: 0733-9372

Journal article

Allingham RR, deKater AW, Ethier CR, 1996, Schlemm's canal and primary open angle glaucoma: Correlation between Schlemm's canal dimensions and outflow facility, EXPERIMENTAL EYE RESEARCH, Vol: 62, Pages: 101-109, ISSN: 0014-4835

Journal article

Steinman DA, Ethier CR, Zhang X, Karpik SRet al., 1995, Effect of flow waveform on anastomotic wall shear stress patterns, Pages: 173-174

Wall shear stress fields in a bypass graft model are dependent on waveform shape, and hence on the graft implantation site within the circulatory system. If intimal thickening on the bed of the host is influenced by the motion of a fluid stagnation point, the grafts in the peripheral circulation may be more susceptible to the development of bed intimal hyperplasia than grafts in the coronary and abdominal circulation. Histological studies of the distribution of the distal anastomotic intimal hyperplasia at these different anatomical locations are needed to test this hypothesis.

Conference paper

ETHIER CR, COLOMA FM, DEKATER AW, ALLINGHAM RRet al., 1995, RETROPERFUSION STUDIES OF THE AQUEOUS OUTFLOW SYSTEM .2. STUDIES IN HUMAN EYES, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 36, Pages: 2466-2475, ISSN: 0146-0404

Journal article

SIT AJ, COLOMA FM, ETHIER CR, ALLINGHAM RR, DEKATER AW, JOHNSON Met al., 1995, AN EVALUATION OF PORE DENSITY AND ITS RELATIONSHIP TO AQUEOUS OUTFLOW FACILITY, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 36, Pages: S729-S729, ISSN: 0146-0404

Journal article

ETHIER CR, COLOMA FM, 1995, FURTHER-STUDIES OF INNER WALL PORE FORMATION, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 36, Pages: S606-S606, ISSN: 0146-0404

Journal article

Ross Ethier C, Moore JA, Steinman DA, Martin AJ, Rutt BKet al., 1995, Flow simulations in a physiological arterial bifurcation, Pages: 471-472

The feasibility of combining magnetic resonance imaging of excised specimens with numerical blood flow simulations is demonstrated to provide detailed velocity and wall shear stress distributions in physiological arterial geometries. Observed wall shear stress and velocity patterns are qualitatively consistent with previous studies on flow in bifurcations. Notable differences between flow patterns observed in this geometry and those seen in idealized geometries include more severe circumferential shear stress variations in the physiologic geometry, and only modestly elevated shears at the flow divider apex.

Conference paper

Moore JA, Ethier CR, 1995, Efficient scheme for analysis of oxygen mass transfer in large arteries, Pages: 21-22

A linearized model for oxygen transport is presented which accounts for oxygen exchange between plasma and hemoglobin, yet it avoids the computational complexity of the full coupled problem. The efficiency of this model is demonstrated by applying it to the simple Graetz-Nusselt problem, as well as for flow through a stenosis.

Conference paper

ACKERMAN JD, COTTRELL CM, ETHIER CR, ALLEN DG, SPELT JKet al., 1995, A WALL-JET TO MEASURE THE ATTACHMENT STRENGTH OF ZEBRA MUSSELS, CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, Vol: 52, Pages: 126-135, ISSN: 0706-652X

Journal article

Steinman DA, Ross Ethier C, Zhang X, Karpik Set al., 1994, Effects of local geometry on anastomotic flow patterns, Pages: 433-434

The preferential distribution of intimal hyperplasia in distal anastomoses is hypothesized to have a hemodynamic origin. In this abstract, the effects of local geometry - including toe curvature, graft hooding and bed hyperplasia - on wall shear stress patterns are investigated. Each of these geometrical factors is shown to influence wall shear stress patterns in the graft-host region.

Conference paper

Ross Ethier C, Steinman DA, Kunov MJ, Ojha Met al., 1994, Calculations of flow and platelet residence times in a modeled stenosis, Pages: 393-394

Biochemical factors released from formed elements in the blood, e.g. platelet-derived growth factor, have been implicated in several arterial diseases. It is therefore useful to quantitate where blood-borne particles travel in complex flowfields, and how long they remain there. In this study, the concept of a volumetric residence time (VRT), proportional to particle density and residence duration, is introduced. In order to demonstrate this concept, unsteady flow in a modeled stenosis is numerically simulated, and particle paths and VRTs are computed from the resulting velocity field. If only platelets 'activated' by high shear are considered, particle residence times are highest in the throat of the stenosis, and relatively low in recirculation regions distal to the stenosis.

Conference paper

BALLYK PD, STEINMAN DA, ETHIER CR, 1994, SIMULATION OF NON-NEWTONIAN BLOOD-FLOW IN AN END-TO-SIDE ANASTOMOSIS, BIORHEOLOGY, Vol: 31, Pages: 565-586, ISSN: 0006-355X

Journal article

ETHIER CR, STEINMAN DA, 1994, EXACT FULLY 3D NAVIER-STOKES SOLUTIONS FOR BENCHMARKING, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Vol: 19, Pages: 369-375, ISSN: 0271-2091

Journal article

ACKERMAN JD, WONG L, ETHIER CR, ALLEN DG, SPELT JKet al., 1994, PRESTON-STATIC TUBES FOR THE MEASUREMENT OF WALL SHEAR-STRESS, JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 116, Pages: 645-649, ISSN: 0098-2202

Journal article

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