Publications

BibTex format

@article{Webster:2017:10.1371/journal.pone.0179521,
author = {Webster, L and Groskreutz, D and Grinbergs-Saull, A and Howard, R and O'Brien, JT and Mountain, G and Banerjee, S and Woods, B and Perneczky, R and Lafortune, L and Roberts, C and McCleery, J and Pickett, J and Bunn, F and Challis, D and Charlesworth, G and Featherstone, K and Fox, C and Goodman, C and Jones, R and Lamb, S and Moniz-Cook, E and Schneider, J and Shepperd, S and Surr, C and Thompson-Coon, J and Ballard, C and Brayne, C and Burns, A and Clare, L and Garrard, P and Kehoe, P and Passmore, P and Holmes, C and Maidment, I and Robinson, L and Livingston, G},
doi = {10.1371/journal.pone.0179521},
journal = {PLOS One},
title = {Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations},
url = {http://dx.doi.org/10.1371/journal.pone.0179521},
volume = {12},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThere are no disease-modifying treatments for dementia. There is also no consensus on disease modifying outcomes. We aimed to produce the first evidence-based consensus on core outcome measures for trials of disease modification in mild-to-moderate dementia.Methods and findingsWe defined disease-modification interventions as those aiming to change the underlying pathology. We systematically searched electronic databases and previous systematic reviews for published and ongoing trials of disease-modifying treatments in mild-to-moderate dementia. We included 149/22,918 of the references found; with 81 outcome measures from 125 trials. Trials involved participants with Alzheimer’s disease (AD) alone (n = 111), or AD and mild cognitive impairment (n = 8) and three vascular dementia. We divided outcomes by the domain measured (cognition, activities of daily living, biological markers, neuropsychiatric symptoms, quality of life, global). We calculated the number of trials and of participants using each outcome. We detailed psychometric properties of each outcome. We sought the views of people living with dementia and family carers in three cities through Alzheimer’s society focus groups. Attendees at a consensus conference (experts in dementia research, disease-modification and harmonisation measures) decided on the core set of outcomes using these results. Recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs. Cognition should be measured by Mini Mental State Examination or Alzheimer's Disease Assessment Scale-Cognitive Subscale. MRIs would be optional for patients. We also made recommendations for measuring important, but non-core domains which may not change despite disease modification.LimitationsMost trials were about AD. Specific instruments may be superseded. We searched one database for psychometric properties.InterpretationThis is the first review to ident
AU  - Webster,L
AU  - Groskreutz,D
AU  - Grinbergs-Saull,A
AU  - Howard,R
AU  - O'Brien,JT
AU  - Mountain,G
AU  - Banerjee,S
AU  - Woods,B
AU  - Perneczky,R
AU  - Lafortune,L
AU  - Roberts,C
AU  - McCleery,J
AU  - Pickett,J
AU  - Bunn,F
AU  - Challis,D
AU  - Charlesworth,G
AU  - Featherstone,K
AU  - Fox,C
AU  - Goodman,C
AU  - Jones,R
AU  - Lamb,S
AU  - Moniz-Cook,E
AU  - Schneider,J
AU  - Shepperd,S
AU  - Surr,C
AU  - Thompson-Coon,J
AU  - Ballard,C
AU  - Brayne,C
AU  - Burns,A
AU  - Clare,L
AU  - Garrard,P
AU  - Kehoe,P
AU  - Passmore,P
AU  - Holmes,C
AU  - Maidment,I
AU  - Robinson,L
AU  - Livingston,G
DO  - 10.1371/journal.pone.0179521
PY  - 2017///
SN  - 1932-6203
TI  - Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0179521
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404608300028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/50099
VL  - 12
ER  -

Download

DrRobertPerneczky

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)