Imperial College London
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Professor Shoumitro (Shoumi) Deb

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 4161s.deb CV

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brizard:2021:10.1192/bjo.2021.55,
author = {Brizard, BA and Limbu, B and Baeza-Velasco, C and Deb, S},
doi = {10.1192/bjo.2021.55},
journal = {BJPsych Open},
pages = {1--21},
title = {Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis},
url = {http://dx.doi.org/10.1192/bjo.2021.55},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPsychiatric disorders, such as depression and anxiety, are commonly associated with epilepsy in the general population, but the relationship between psychiatric disorders and epilepsy among adults with intellectual disabilities is unclear.AimsTo conduct a systematic review and meta-analysis to assess whether epilepsy is associated with an increased rate of psychiatric disorders in adults with intellectual disabilities.MethodWe included literature published between 1985 and 2020 from four databases, and hand-searched six relevant journals. We assessed risk of bias by using SIGN 50 and the Cochrane risk of bias tool. Several meta-analyses were carried out.ResultsWe included 29 papers involving data on 9594 adults with intellectual disabilities, 3180 of whom had epilepsy and 6414 did not. Of the 11 controlled studies that compared the overall rate of psychiatric disorders between the epilepsy and non-epilepsy groups, seven did not show any significant inter-group difference. Meta-analysis was possible on pooled data from seven controlled studies, which did not show any significant inter-group difference in the overall rate of psychiatric disorders. The rates of psychotic disorders, depressive disorders and anxiety disorders were significantly higher in the non-epilepsy control groups compared with the epilepsy group, with effect sizes of 0.29, 0.47 and 0.58, respectively. Epilepsy-related factors did not show any definite association with psychiatric disorders.ConclusionsIt is difficult to pool data from such heterogeneous studies and draw any definitive conclusion because most studies lacked an appropriately matched control group, which will be required for future studies.
AU  - Brizard,BA
AU  - Limbu,B
AU  - Baeza-Velasco,C
AU  - Deb,S
DO  - 10.1192/bjo.2021.55
EP  - 21
PY  - 2021///
SN  - 2056-4724
SP  - 1
TI  - Association between epilepsy and psychiatric disorders in adults with intellectual disabilities: systematic review and meta-analysis
T2  - BJPsych Open
UR  - http://dx.doi.org/10.1192/bjo.2021.55
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000646189800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.cambridge.org/core/journals/bjpsych-open/article/association-between-epilepsy-and-psychiatric-disorders-in-adults-with-intellectual-disabilities-systematic-review-and-metaanalysis/98CC91BB081FD973EF8088562C2D233F
UR  - http://hdl.handle.net/10044/1/94255
VL  - 7
ER  -
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