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BibTex format

@article{Thornhill:2019:10.1097/QAD.0000000000002344,
author = {Thornhill, J and Lynch, K and Skelton, J and Dorner, M and Khan, M and Martin, G and Hoare, J and Peake, S and Frater, J and Fidler, S},
doi = {10.1097/QAD.0000000000002344},
journal = {AIDS},
pages = {2268--2271},
title = {Vedolizumab use and the associations between α4β7 expression and HIV reservoir in the gut during treated primary HIV infection},
url = {http://dx.doi.org/10.1097/QAD.0000000000002344},
volume = {33},
year = {2019}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Latent HIV infection in gut CD4+ cells is a barrier to HIV eradication. α4β7 integrin is a gut homing marker expressed on CD4+ cells. Monoclonal antibodies against α4β are being trialled to induce HIV remission. Using gut biopsy samples taken from a cohort of HIV+ individuals treated during primary HIV infection, we characterised β7 expression and HIV DNA in terminal ileum and rectum. We demonstrate an association between HIV DNA and β7 expression in gut, and present the case of a HIV+ individual treated with an α4β7 antibody; finding no evidence of HIV remission by humanized murine viral outgrowth assay.
AU  - Thornhill,J
AU  - Lynch,K
AU  - Skelton,J
AU  - Dorner,M
AU  - Khan,M
AU  - Martin,G
AU  - Hoare,J
AU  - Peake,S
AU  - Frater,J
AU  - Fidler,S
DO  - 10.1097/QAD.0000000000002344
EP  - 2271
PY  - 2019///
SN  - 0269-9370
SP  - 2268
TI  - Vedolizumab use and the associations between α4β7 expression and HIV reservoir in the gut during treated primary HIV infection
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000002344
UR  - http://hdl.handle.net/10044/1/70971
VL  - 33
ER  -

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Professor Sarah Fidler BSc. MBBS. FRCP. PhD

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