Imperial College London
Portrait Picture

Professor Sarah Fidler BSc. MBBS. FRCP. PhD

Faculty of Medicine, Department of Infectious Disease

Professor of HIV and Communicable Diseases
 
 
 
//

Contact

 

+44 (0)20 7594 6230s.fidler

 
 
//

Location

 

clinical trial centre Winston Churchill wingMedical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Martin:2019:10.1101/580308,
author = {Martin, GE and Pace, M and Shearer, F and Zilber, E and Hurst, J and Meyerowitz, J and Thornhill, JP and Lwanga, J and Brown, H and Robinson, N and Hopkins, E and Olejniczak, N and Nwokolo, N and Fox, J and Fidler, S and Willberg, CB and Frater, J},
doi = {10.1101/580308},
title = {HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion},
url = {http://dx.doi.org/10.1101/580308},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Initiation of antiretroviral therapy (ART) in early compared with chronic HIV infection is associated with a smaller HIV reservoir. This longitudinal analysis of 63 individuals who commenced ART during primary HIV infection (PHI) investigates which pre-and post-therapy factors associate most closely with reservoir size (HIV DNA) following treatment initiation during PHI. The best predictor of reservoir size at one-year was pre-ART HIV DNA which was in turn significantly associated with CD8 memory differentiation (effector memory, naïve and T-bet<jats:sup>neg</jats:sup>Eomes<jats:sup>neg</jats:sup>subsets), CD8 T cell activation (CD38 expression) and PD-1 and Tim-3 expression on memory CD4 T cells. No associations were found for any immunological variables following one-year of ART. HIV reservoir size is determined around the time of ART initiation in individuals treated during PHI. CD8 T cell activation and memory expansion are linked to HIV reservoir size, suggesting the importance of the initial host-viral interplay in eventual reservoir size.</jats:p>
AU  - Martin,GE
AU  - Pace,M
AU  - Shearer,F
AU  - Zilber,E
AU  - Hurst,J
AU  - Meyerowitz,J
AU  - Thornhill,JP
AU  - Lwanga,J
AU  - Brown,H
AU  - Robinson,N
AU  - Hopkins,E
AU  - Olejniczak,N
AU  - Nwokolo,N
AU  - Fox,J
AU  - Fidler,S
AU  - Willberg,CB
AU  - Frater,J
DO  - 10.1101/580308
PY  - 2019///
TI  - HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion
UR  - http://dx.doi.org/10.1101/580308
ER  -
Download