Imperial College London
Alternate

Professor Steve Gentleman

Faculty of Medicine, Department of Brain Sciences

Professor of Neuropathology
 
 
 
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Contact

 

+44 (0)20 7594 6586s.gentleman Website

 
 
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Location

 

E407Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tsalenchuk:2023:10.1038/s41531-023-00568-z,
author = {Tsalenchuk, M and Gentleman, S and Marzi, S},
doi = {10.1038/s41531-023-00568-z},
journal = {npj Parkinson's Disease},
pages = {1--12},
title = {Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease},
url = {http://dx.doi.org/10.1038/s41531-023-00568-z},
volume = {9},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sporadic Parkinson’s disease (PD) is a progressive neurodegenerative disease, with a complex risk structure thought to be influenced by interactions between genetic variants and environmental exposures, although the full aetiology is unknown. Environmental factors, including pesticides, have been reported to increase the risk of developing the disease. Growing evidence suggests epigenetic changes are key mechanisms by which these environmental factors act upon gene regulation, in disease-relevant cell types. We present a systematic review critically appraising and summarising the current body of evidence of the relationship between epigenetic mechanisms and environmental risk factors in PD to inform future research in this area.   Epigenetic studies of relevant environmental risk factors in animal and cell models have yielded promising results, however, research in humans is just emerging. While published studies in humans are currently relatively limited, the importance of the field for the elucidation of molecular mechanisms of pathogenesis opens clear and promising avenues for the future of PD research. Carefully designed epidemiological studies carried out in PD patients hold great potential to uncover disease-relevant gene regulatory mechanisms. Therefore, to advance this burgeoning field, we recommend broadening the scope of investigations to include more environmental exposures, increasing sample sizes, focusing on disease-relevant cell types, and recruiting more diverse cohorts.
AU  - Tsalenchuk,M
AU  - Gentleman,S
AU  - Marzi,S
DO  - 10.1038/s41531-023-00568-z
EP  - 12
PY  - 2023///
SN  - 2373-8057
SP  - 1
TI  - Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease
T2  - npj Parkinson's Disease
UR  - http://dx.doi.org/10.1038/s41531-023-00568-z
UR  - https://www.nature.com/articles/s41531-023-00568-z
UR  - http://hdl.handle.net/10044/1/106102
VL  - 9
ER  -
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