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@article{Alafuzoff:2014:10.1007/s00702-014-1304-1,
author = {Alafuzoff, I and Pikkarainen, M and Neumann, M and Arzberger, T and Al-Sarraj, S and Bodi, I and Bogdanovic, N and Bugiani, O and Ferrer, I and Gelpi, E and Gentleman, S and Giaccone, G and Graeber, MB and Hortobagyi, T and Ince, PG and Ironside, JW and Kavantzas, N and King, A and Korkolopoulou, P and Kovacs, GG and Meyronet, D and Monoranu, C and Nilsson, T and Parchi, P and Patsouris, E and Revesz, T and Roggendorf, W and Rozemuller, A and Seilhean, D and Streichenberger, N and Thal, DR and Wharton, SB and Kretzschmar, H},
doi = {10.1007/s00702-014-1304-1},
journal = {Journal of Neural Transmission},
pages = {957--972},
title = {Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium},
url = {http://dx.doi.org/10.1007/s00702-014-1304-1},
volume = {122},
year = {2014}
}

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TY  - JOUR
AB  - The BrainNet Europe consortium assessed thereproducibility in the assignment of the type of frontotemporallobar degeneration (FTLD) with TAR DNA-bindingprotein (TDP) 43 following current recommendations. Theagreement rates were influenced by the immunohistochemical(IHC) method and by the classification strategy followed.p62-IHC staining yielded good uniform quality ofstains, but the most reliable results were obtained implementingspecific Abs directed against the hallmark proteinTDP43. Both assessment of the type and the extent of lesionswere influenced by the Abs and by the quality of stain.Assessment of the extent of the lesions yielded poor resultsrepeatedly; thus, the extent of pathology should not be usedin diagnostic consensus criteria. Whilst 31 neuropathologiststyped 30 FTLD-TDP cases, inter-rater agreement rangedfrom 19 to 100 per cent, being highest when applyingphosphorylated TDP43/IHC. The agreement was highestwhen designating Type C or Type A/B. In contrast, there wasa poor agreement when attempting to separate Type A or Type B FTLD-TDP. In conclusion, we can expect that neuropathologist,independent of his/her familiarity with FTLDTDPpathology, can identify a TDP43-positive FTLD case.The goal should be to state a Type (A, B, C, D) or a mixture ofTypes (A/B, A/C or B/C). Neuropathologists, other cliniciansand researchers should be aware of the pitfalls whilstdoing so. Agreement can be reached in an inter-laboratorysetting regarding Type C cases with thick and long neurites,whereas the differentiation between Types A and B may bemore troublesome.
AU  - Alafuzoff,I
AU  - Pikkarainen,M
AU  - Neumann,M
AU  - Arzberger,T
AU  - Al-Sarraj,S
AU  - Bodi,I
AU  - Bogdanovic,N
AU  - Bugiani,O
AU  - Ferrer,I
AU  - Gelpi,E
AU  - Gentleman,S
AU  - Giaccone,G
AU  - Graeber,MB
AU  - Hortobagyi,T
AU  - Ince,PG
AU  - Ironside,JW
AU  - Kavantzas,N
AU  - King,A
AU  - Korkolopoulou,P
AU  - Kovacs,GG
AU  - Meyronet,D
AU  - Monoranu,C
AU  - Nilsson,T
AU  - Parchi,P
AU  - Patsouris,E
AU  - Revesz,T
AU  - Roggendorf,W
AU  - Rozemuller,A
AU  - Seilhean,D
AU  - Streichenberger,N
AU  - Thal,DR
AU  - Wharton,SB
AU  - Kretzschmar,H
DO  - 10.1007/s00702-014-1304-1
EP  - 972
PY  - 2014///
SN  - 1435-1463
SP  - 957
TI  - Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium
T2  - Journal of Neural Transmission
UR  - http://dx.doi.org/10.1007/s00702-014-1304-1
UR  - http://hdl.handle.net/10044/1/32119
VL  - 122
ER  -

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