Imperial College London
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Dr Shlomi Haar

Faculty of Medicine, Department of Brain Sciences

Edmond and Lily Safra Research Fellow and UK DRI Fellow
 
 
 
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Contact

 

s.haar Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sha:2022:10.1038/s41380-022-01452-7,
author = {Sha, Z and van, Rooij D and Anagnostou, E and Arango, C and Auzias, G and Behrmann, M and Bernhardt, B and Bolte, S and Busatto, GF and Calderoni, S and Calvo, R and Daly, E and Deruelle, C and Duan, M and Duran, FLS and Durston, S and Ecker, C and Ehrlich, S and Fair, D and Fedor, J and Fitzgerald, J and Floris, DL and Franke, B and Freitag, CM and Gallagher, L and Glahn, DC and Haar, S and Hoekstra, L and Jahanshad, N and Jalbrzikowski, M and Janssen, J and King, JA and Lazaro, L and Luna, B and McGrath, J and Medland, SE and Muratori, F and Murphy, DGM and Neufeld, J and O'Hearn, K and Oranje, B and Parellada, M and Pariente, JC and Postema, MC and Remnelius, KL and Retico, A and Rosa, PGP and Rubia, K and Shook, D and Tammimies, K and Taylor, MJ and Tosetti, M and Wallace, GL and Zhou, F and Thompson, PM and Fisher, SE and Buitelaar, JK and Francks, C},
doi = {10.1038/s41380-022-01452-7},
journal = {Molecular Psychiatry},
pages = {2114--2125},
title = {Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium},
url = {http://dx.doi.org/10.1038/s41380-022-01452-7},
volume = {27},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of structural network effects have not previously been characterized. Inter-regional morphological covariance analysis can capture network connectivity between different cortical areas at the macroscale level. Here, we used cortical thickness data from 1455 individuals with ASD and 1560 controls, across 43 independent datasets of the ENIGMA consortium’s ASD Working Group, to assess hemispheric asymmetries of intra-individual structural covariance networks, using graph theory-based topological metrics. Compared with typical features of small-world architecture in controls, the ASD sample showed significantly altered average asymmetry of networks involving the fusiform, rostral middle frontal, and medial orbitofrontal cortex, involving higher randomization of the corresponding right-hemispheric networks in ASD. A network involving the superior frontal cortex showed decreased right-hemisphere randomization. Based on comparisons with meta-analyzed functional neuroimaging data, the altered connectivity asymmetry particularly affected networks that subserve executive functions, language-related and sensorimotor processes. These findings provide a network-level characterization of altered left-right brain asymmetry in ASD, based on a large combined sample. Altered asymmetrical brain development in ASD may be partly propagated among spatially distant regions through structural connectivity.
AU  - Sha,Z
AU  - van,Rooij D
AU  - Anagnostou,E
AU  - Arango,C
AU  - Auzias,G
AU  - Behrmann,M
AU  - Bernhardt,B
AU  - Bolte,S
AU  - Busatto,GF
AU  - Calderoni,S
AU  - Calvo,R
AU  - Daly,E
AU  - Deruelle,C
AU  - Duan,M
AU  - Duran,FLS
AU  - Durston,S
AU  - Ecker,C
AU  - Ehrlich,S
AU  - Fair,D
AU  - Fedor,J
AU  - Fitzgerald,J
AU  - Floris,DL
AU  - Franke,B
AU  - Freitag,CM
AU  - Gallagher,L
AU  - Glahn,DC
AU  - Haar,S
AU  - Hoekstra,L
AU  - Jahanshad,N
AU  - Jalbrzikowski,M
AU  - Janssen,J
AU  - King,JA
AU  - Lazaro,L
AU  - Luna,B
AU  - McGrath,J
AU  - Medland,SE
AU  - Muratori,F
AU  - Murphy,DGM
AU  - Neufeld,J
AU  - O'Hearn,K
AU  - Oranje,B
AU  - Parellada,M
AU  - Pariente,JC
AU  - Postema,MC
AU  - Remnelius,KL
AU  - Retico,A
AU  - Rosa,PGP
AU  - Rubia,K
AU  - Shook,D
AU  - Tammimies,K
AU  - Taylor,MJ
AU  - Tosetti,M
AU  - Wallace,GL
AU  - Zhou,F
AU  - Thompson,PM
AU  - Fisher,SE
AU  - Buitelaar,JK
AU  - Francks,C
DO  - 10.1038/s41380-022-01452-7
EP  - 2125
PY  - 2022///
SN  - 1359-4184
SP  - 2114
TI  - Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium
T2  - Molecular Psychiatry
UR  - http://dx.doi.org/10.1038/s41380-022-01452-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752757600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41380-022-01452-7
UR  - http://hdl.handle.net/10044/1/95078
VL  - 27
ER  -
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