Imperial College London
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MsSarrahPeerbux

Faculty of Medicine, Department of Surgery & Cancer

Clinical Trial Manager
 
 
 
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Contact

 

s.peerbux

 
 
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Location

 

East WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Webb:2020:10.2196/22833,
author = {Webb, J and Peerbux, S and Smittenaar, P and Siddiqui, S and Sherwani, Y and Ahmed, M and MacRae, H and Puri, H and Bhalla, S and Majeed, A},
doi = {10.2196/22833},
journal = {JMIR Mental Health},
title = {Preliminary outcomes of a digital therapeutic intervention for smoking cessation in adult smokers: randomized controlled trial},
url = {http://dx.doi.org/10.2196/22833},
volume = {7},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Tobacco smoking remains the leading cause of preventable death and disease worldwide. Digital interventions delivered through smartphones offer a promising alternative to traditional methods, but little is known about their effectiveness.Objective: Our objective was to test the preliminary effectiveness of Quit Genius, a novel digital therapeutic intervention for smoking cessation.Methods: A 2-arm, single-blinded, parallel-group randomized controlled trial design was used. Participants were recruited via referrals from primary care practices and social media advertisements in the United Kingdom. A total of 556 adult smokers (aged 18 years or older) smoking at least 5 cigarettes a day for the past year were recruited. Of these, 530 were included for the final analysis. Participants were randomized to one of 2 interventions. Treatment consisted of a digital therapeutic intervention for smoking cessation consisting of a smartphone app delivering cognitive behavioral therapy content, one-to-one coaching, craving tools, and tracking capabilities. The control intervention was very brief advice along the Ask, Advise, Act model. All participants were offered nicotine replacement therapy for 3 months. Participants in a random half of each arm were pseudorandomly assigned a carbon monoxide device for biochemical verification. Outcomes were self-reported via phone or online. The primary outcome was self-reported 7-day point prevalence abstinence at 4 weeks post quit date.Results: A total of 556 participants were randomized (treatment: n=277; control: n=279). The intention-to-treat analysis included 530 participants (n=265 in each arm; 11 excluded for randomization before trial registration and 15 for protocol violations at baseline visit). By the quit date (an average of 16 days after randomization), 89.1% (236/265) of those in the treatment arm were still actively engaged. At the time of the primary outcome, 74.0% (196/265) of participants were still engagi
AU  - Webb,J
AU  - Peerbux,S
AU  - Smittenaar,P
AU  - Siddiqui,S
AU  - Sherwani,Y
AU  - Ahmed,M
AU  - MacRae,H
AU  - Puri,H
AU  - Bhalla,S
AU  - Majeed,A
DO  - 10.2196/22833
PY  - 2020///
SN  - 2368-7959
TI  - Preliminary outcomes of a digital therapeutic intervention for smoking cessation in adult smokers: randomized controlled trial
T2  - JMIR Mental Health
UR  - http://dx.doi.org/10.2196/22833
UR  - http://hdl.handle.net/10044/1/87141
VL  - 7
ER  -
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