Imperial College London
Alternate

DrSanjayPopat

Faculty of Medicine, National Heart & Lung Institute

Reader in Cancer Medicine
 
 
 
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Contact

 

+44 (0)20 7808 2132s.popat Website

 
 
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Location

 

Royal Marsden HospitalThe Royal Marsden Hospital

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Summary

 

Publications

Citation

BibTex format

@article{Rini:2005:10.1200/JCO.2005.01.186,
author = {Rini, BI and Small, EJ},
doi = {10.1200/JCO.2005.01.186},
journal = {J Clin Oncol},
pages = {1028--1043},
title = {Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma.},
url = {http://dx.doi.org/10.1200/JCO.2005.01.186},
volume = {23},
year = {2005}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PURPOSE: To review the biology of renal cell carcinoma (RCC) leading to vascular endothelial growth factor (VEGF) overexpression and the clinical results of VEGF blockade in metastatic RCC. METHODS: A review of relevant published literature regarding VEGF, von Hippel-Lindau (VHL) gene inactivation and VEGF overexpression in RCC was performed. Further, a review of the mechanism, toxicity, and clinical development of VEGF-targeted therapy in metastatic RCC was undertaken. RESULTS: VEGF is the major proangiogenic protein that exerts a biologic effect through interaction with cellular receptors. The majority of sporadic clear-cell RCC tumors are characterized by VHL tumor suppressor gene inactivation. The resulting VHL gene silencing leads to VEGF overexpression. An antibody to VEGF (bevacizumab) has demonstrated a significant prolongation of time to disease progression compared with placebo in patients with metastatic RCC. Small molecules with inhibitory effects against the VEGF receptor have undergone initial clinical testing in metastatic RCC with substantial objective response rates. CONCLUSION: Therapeutic targeting of VEGF in RCC has strong biologic rationale and preliminary clinical efficacy. Further investigation will determine the optimal timing, sequence, and utility of these agents in RCC.
AU  - Rini,BI
AU  - Small,EJ
DO  - 10.1200/JCO.2005.01.186
EP  - 1043
PY  - 2005///
SN  - 0732-183X
SP  - 1028
TI  - Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma.
T2  - J Clin Oncol
UR  - http://dx.doi.org/10.1200/JCO.2005.01.186
UR  - https://www.ncbi.nlm.nih.gov/pubmed/15534359
VL  - 23
ER  -
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