Imperial College London
Alternate

DrSanjayPopat

Faculty of Medicine, National Heart & Lung Institute

Reader in Cancer Medicine
 
 
 
//

Contact

 

+44 (0)20 7808 2132s.popat Website

 
 
//

Location

 

Royal Marsden HospitalThe Royal Marsden Hospital

//

Summary

 

Publications

Citation

BibTex format

@article{Popat:2008:10.1038/ncponc1090,
author = {Popat, S and Smith, IE},
doi = {10.1038/ncponc1090},
journal = {Nat Clin Pract Oncol},
title = {Therapy Insight: anthracyclines and trastuzumab-the optimal management of cardiotoxic side effects.},
url = {http://dx.doi.org/10.1038/ncponc1090},
year = {2008}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Anthracyclines and trastuzumab are key agents in the management of patients with breast cancer, and have revolutionized the management of both early-stage and advanced-stage disease. The use of anthracyclines, however, can be compromised by the potential for cardiotoxicity; trastuzumab also has the potential for causing cardiotoxicity in patients receiving concurrent or prior anthracyclines. Although its development is treatment limiting, cardiotoxicity can be minimized with appropriate clinical care and drug scheduling. We discuss the efficacy of trastuzumab, its potential for cardiac compromise, and its interaction with anthracyclines. We highlight biological mechanisms that might be responsible for cardiotoxicity, describe the established and trial schedules of both agents, and discuss clinical strategies used to minimize the risk of developing cardiac failure through appropriate scheduling of trastuzumab with anthracyclines.
AU  - Popat,S
AU  - Smith,IE
DO  - 10.1038/ncponc1090
PY  - 2008///
SN  - 1743-4262
TI  - Therapy Insight: anthracyclines and trastuzumab-the optimal management of cardiotoxic side effects.
T2  - Nat Clin Pract Oncol
UR  - http://dx.doi.org/10.1038/ncponc1090
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18364726&query_hl=1
ER  -
Download