Imperial College London
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ProfessorSanjayPrasad

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiomyopathy
 
 
 
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Contact

 

+44 (0)20 7352 8121s.prasad

 
 
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Location

 

CMR UnitRoyal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Japp:2016:10.1016/j.jacc.2016.03.590,
author = {Japp, AG and Gulati, A and Cook, SA and Cowie, MR and Prasad, SK},
doi = {10.1016/j.jacc.2016.03.590},
journal = {Journal of the American College of Cardiology},
pages = {2996--3010},
title = {The diagnosis and evaluation of dilated cardiomyopathy},
url = {http://dx.doi.org/10.1016/j.jacc.2016.03.590},
volume = {67},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dilated cardiomyopathy (DCM) is best understood as the final common response of myocardium to diverse genetic and environmental insults. A rigorous work-up can exclude alternative causes of left ventricular (LV) dilation and dysfunction, identify etiologies that may respond to specific treatments, and guide family screening. A significant proportion of DCM cases have an underlying genetic or inflammatory basis. Measurement of LV size and ejection fraction remain central to diagnosis, risk stratification, and treatment, but other aspects of cardiac remodeling inform prognosis and carry therapeutic implications. Assessment of myocardial fibrosis predicts both risk of sudden cardiac death and likelihood of LV functional recovery, and has significant potential to guide patient selection for cardioverter-defibrillator implantation. Detailed mitral valve assessment is likely to assume increasing importance with the emergence of percutaneous interventions for functional mitral regurgitation. Detection of pre-clinical DCM could substantially reduce morbidity and mortality by allowing early instigation of cardioprotective therapy.
AU  - Japp,AG
AU  - Gulati,A
AU  - Cook,SA
AU  - Cowie,MR
AU  - Prasad,SK
DO  - 10.1016/j.jacc.2016.03.590
EP  - 3010
PY  - 2016///
SN  - 1558-3597
SP  - 2996
TI  - The diagnosis and evaluation of dilated cardiomyopathy
T2  - Journal of the American College of Cardiology
UR  - http://dx.doi.org/10.1016/j.jacc.2016.03.590
UR  - http://hdl.handle.net/10044/1/45801
VL  - 67
ER  -
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