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@article{Hendriks:2020:10.3389/fcell.2020.602278,
author = {Hendriks, M and Ramasamy, S},
doi = {10.3389/fcell.2020.602278},
journal = {Frontiers in Cell and Developmental Biology},
title = {Blood vessels and vascular niches in bone development and physiological remodelling},
url = {http://dx.doi.org/10.3389/fcell.2020.602278},
volume = {8},
year = {2020}
}

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TY  - JOUR
AB  - Recent advances in our understanding of blood vessels and vascular niches in bone convey their critical importance in regulating bone development and physiology. The contribution of blood vessels in bone functions and remodeling has recently gained enormous interest because of their therapeutic potential. The mammalian skeletal system performs multiple functions in the body to regulate growth, homeostasis and metabolism. Blood vessels provide support to various cell types in bone and maintain functional niches in the bone marrow microenvironment. Heterogeneity within blood vessels and niches indicate the importance of specialized vascular niches in regulating skeletal functions. In this review, we discuss physiology of bone vasculature and their specialized niches for hematopoietic stem cells and mesenchymal progenitor cells. We provide clinical and experimental information available on blood vessels during physiological bone remodeling.
AU  - Hendriks,M
AU  - Ramasamy,S
DO  - 10.3389/fcell.2020.602278
PY  - 2020///
SN  - 2296-634X
TI  - Blood vessels and vascular niches in bone development and physiological remodelling
T2  - Frontiers in Cell and Developmental Biology
UR  - http://dx.doi.org/10.3389/fcell.2020.602278
UR  - http://hdl.handle.net/10044/1/84926
VL  - 8
ER  -

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