Imperial College London
Portrait Picture

ProfessorShiraneeSriskandan

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

s.sriskandan

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACWBCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leonard:2019:10.1111/1471-0528.15415,
author = {Leonard, A and Wright, A and Saavedra-Campos, M and Lamagni, T and Cordery, R and Nicholls, M and Domoney, C and Sriskandan, S and Balasegaram, S},
doi = {10.1111/1471-0528.15415},
journal = {BJOG: An International Journal of Obstetrics and Gynaecology},
pages = {44--53},
title = {Severe group A streptococcal infections in mothers and their newborns in London and the South East, 2010-2016: assessment of risk and audit of public health management},
url = {http://dx.doi.org/10.1111/1471-0528.15415},
volume = {126},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectiveWe describe cases of invasive group A Streptococcus (iGAS) in mothers or neonates and assess management according to national guidelines, which recommend administering antibiotics to both mother and neonate if either develops iGAS infection within 28 days of birth and investigation of clusters in maternity units.DesignCrosssectional retrospective study.Setting and populationNotified confirmed iGAS cases in either mothers or neonates with onset within 28 days of birth in London and the South East of England between 2010 and 2016MethodReview of public health records of notified cases.Main outcome measuresIncidence and onset time of iGAS in postpartum mothers and babies, proportion given prophylaxis, maternity unit clusters within 6 months.ResultsWe identified 134 maternal and 21 neonatal confirmed iGAS infections. The incidence (in 100 000 person years) of iGAS in women within 28 days postpartum was 109 (95% CI 90–127) compared with 1.3 in other females aged 15–44. For neonates the incidence was 1.5 (95% CI 9–23). The median onset time was 2 days postpartum [interquartile range (IQR) 0–5 days] for mothers and 12 days (IQR 7–15 days) for neonates. All eligible mothers and most (109, 89%) eligible neonates received chemoprophylaxis. Of 20 clusters (59 cases of GAS and iGAS) in maternity units, two clusters involved possible transmission. However, in 6 of 15 clusters, GAS isolates were not saved for comparison even after relevant guidance was issued.ConclusionsiGAS infection remains a potential postpartum risk. Prophylaxis among neonates and storage of isolates from maternity cases can be improved.
AU  - Leonard,A
AU  - Wright,A
AU  - Saavedra-Campos,M
AU  - Lamagni,T
AU  - Cordery,R
AU  - Nicholls,M
AU  - Domoney,C
AU  - Sriskandan,S
AU  - Balasegaram,S
DO  - 10.1111/1471-0528.15415
EP  - 53
PY  - 2019///
SN  - 1470-0328
SP  - 44
TI  - Severe group A streptococcal infections in mothers and their newborns in London and the South East, 2010-2016: assessment of risk and audit of public health management
T2  - BJOG: An International Journal of Obstetrics and Gynaecology
UR  - http://dx.doi.org/10.1111/1471-0528.15415
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.15415
UR  - http://hdl.handle.net/10044/1/62341
VL  - 126
ER  -
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