Imperial College London
Alternate

Dr Sana Usman

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Lecturer
 
 
 
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Contact

 

s.usman

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dall'Asta:2020:10.1002/uog.20368,
author = {Dall'Asta, A and Girardelli, S and Usman, S and Lawin-O'Brien, A and Paramasivam, G and Frusca, T and Lees, CC},
doi = {10.1002/uog.20368},
journal = {Ultrasound in Obstetrics and Gynecology},
pages = {368--374},
title = {Etiology and perinatal outcome in periviable fetal growth restriction associated with structural or genetic anomalies},
url = {http://dx.doi.org/10.1002/uog.20368},
volume = {55},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To investigate the aetiology and the perinatal outcome of fetuses diagnosed with periviable fetal growth restriction (FGR) associated with structural defects or genetic anomalies. METHODS: Retrospective study conducted at a referral Fetal Medicine unit. Singleton pregnancies seen between 2005 and 2018 in which FGR, defined by fetal abdominal circumference ≤3rd percentile for the gestational age, was diagnosed between 22+0 -25+6 weeks of gestation were enrolled. The study group included periviable FGR associated with genetic or structural anomalies ("anomalous FGR"), while the control group consisted in structurally and genetically normal FGR ("non-anomalous FGR"). The results of the genetic tests, of the TORCH screening and of the post-mortem examination as well as the perinatal outcomes were investigated. RESULTS: Of 255 cases, 188 fetuses were eligible, of whom 52 (28%) were anomalous FGR and 136 (72%) non-anomalous FGR. Confirmed genetic abnormalities accounted for 17/52 cases (33%) of anomalous FGR, with trisomy 18 constituting over 50% (9/17, 53%). The most common structural defects associated with FGR were CNS abnormalities (13/35, 37%). Overall, 12 cases survived the neonatal period. No differences were found in terms of perinatal survival between anomalous and non-anomalous FGR. CONCLUSIONS: Of anomalous FGR, most are associated with structural defects. The association of structural abnormality with a genetic defect and FGR at periviable gestation was invariably lethal, while the combination of periviable FGR and structural defect in the absence of a confirmed genetic abnormality was associated with survival into infancy in four out of five cases, with an overall chance of perinatal survival of one in three. These data can be used for the counselling of the prospective parents. This article is protected by copyright. All rights reserved.
AU  - Dall'Asta,A
AU  - Girardelli,S
AU  - Usman,S
AU  - Lawin-O'Brien,A
AU  - Paramasivam,G
AU  - Frusca,T
AU  - Lees,CC
DO  - 10.1002/uog.20368
EP  - 374
PY  - 2020///
SN  - 0960-7692
SP  - 368
TI  - Etiology and perinatal outcome in periviable fetal growth restriction associated with structural or genetic anomalies
T2  - Ultrasound in Obstetrics and Gynecology
UR  - http://dx.doi.org/10.1002/uog.20368
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31180600
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.20368
UR  - http://hdl.handle.net/10044/1/70741
VL  - 55
ER  -
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