Imperial College London
Alternate

Dr Sayan Sen

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

sayan.sen

 
 
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Location

 

ICCHSt Mary's Research BuildingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Panoulas:2016,
author = {Panoulas, VF and Ruparelia, N and Franks, R and Sen, S and Ariff, B and Sutaria, N and Frame, A and Nihoyannopoulos, P and Malik, IS and Mikhail, GW},
journal = {J Heart Valve Dis},
pages = {552--556},
title = {The Impact of Gender on Outcomes Following Transcatheter Aortic Valve Implantation: True Effect or Bias?},
url = {https://www.ncbi.nlm.nih.gov/pubmed/28238236},
volume = {25},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transcatheter aortic valve implantation (TAVI) is currently the treatment of choice for patients with severe aortic stenosis (AS) who are unsuitable for surgical aortic valve replacement (SAVR), and is an acceptable alternative for those at high and intermediate surgical risk. In published TAVI registries and meta-analyses, whilst women are significantly older they present with fewer comorbidities compared to men (including coronary artery disease, peripheral vascular disease, diabetes and chronic obstructive pulmonary disease). In response to chronic pressure overload from AS, women have been shown to develop greater levels of left ventricular hypertrophy than men, as well as having a greater preservation of LV ejection fraction (LVEF) and less fibrosis. Following aortic valve replacement, women have been shown to have a faster regression of myocardial hypertrophy, with a significant improvement in LVEF. Following TAVI, female gender seems to be associated with a significantly lower one-year mortality. In the current viewpoint, it is discussed whether these findings reflect a true differential treatment response to TAVI among women, or simply the higher comorbidity burden among males undergoing TAVI.
AU  - Panoulas,VF
AU  - Ruparelia,N
AU  - Franks,R
AU  - Sen,S
AU  - Ariff,B
AU  - Sutaria,N
AU  - Frame,A
AU  - Nihoyannopoulos,P
AU  - Malik,IS
AU  - Mikhail,GW
EP  - 556
PY  - 2016///
SN  - 0966-8519
SP  - 552
TI  - The Impact of Gender on Outcomes Following Transcatheter Aortic Valve Implantation: True Effect or Bias?
T2  - J Heart Valve Dis
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28238236
VL  - 25
ER  -
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