Imperial College London
Alternate

Emeritus ProfessorTimothyWilliams

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor in Airway Disease
 
 
 
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Contact

 

+44 (0)20 7594 3159tim.williams Website

 
 
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Location

 

Office no. 360Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hellewell:1989:10.1111/j.1476-5381.1989.tb11776.x,
author = {Hellewell, PG and Williams, TJ},
doi = {10.1111/j.1476-5381.1989.tb11776.x},
journal = {Br J Pharmacol},
pages = {5--7},
title = {An anti-inflammatory steroid inhibits tissue sensitization by IgE in vivo.},
url = {http://dx.doi.org/10.1111/j.1476-5381.1989.tb11776.x},
volume = {96},
year = {1989}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An anti-inflammatory corticosteroid, dexamethasone, was found to be a potent suppressor of cell sensitization induced by IgE antibody in a model of type I allergic inflammation in vivo. Low doses (approximately less than 10(-10) mol) of dexamethasone, administered intradermally to rabbits 90 min before injection of IgE into the same sites, suppressed local oedema induced by a local challenge with antigen 72 h later. The effect was not due to anti-inflammatory activity persisting in the skin site for the 3 day period. This novel potent activity of the corticosteroid may be an important component of its anti-allergic effect in diseases such as asthma.
AU  - Hellewell,PG
AU  - Williams,TJ
DO  - 10.1111/j.1476-5381.1989.tb11776.x
EP  - 7
PY  - 1989///
SN  - 0007-1188
SP  - 5
TI  - An anti-inflammatory steroid inhibits tissue sensitization by IgE in vivo.
T2  - Br J Pharmacol
UR  - http://dx.doi.org/10.1111/j.1476-5381.1989.tb11776.x
UR  - https://www.ncbi.nlm.nih.gov/pubmed/2924076
VL  - 96
ER  -
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