Imperial College London
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Professor Thomas N Williams

Faculty of Medicine, Department of Surgery & Cancer

Chair in Haemoglobinopathy Research
 
 
 
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Contact

 

tom.williams Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Silaba:2019:10.1016/S2214-109X(18)30491-1,
author = {Silaba, M and Ooko, M and Bottomley, C and Sande, J and Benamore, R and Park, K and Ignas, J and Maitland, K and Mturi, N and Makumi, A and Otiende, M and Kagwanja, S and Safari, S and Ochola, V and Bwanaali, T and Bauni, E and Gleeson, F and Deloria, Knoll M and Adetifa, I and Marsh, K and Williams, TN and Kamau, T and Sharif, S and Levine, OS and Hammitt, LL and Scott, JAG},
doi = {10.1016/S2214-109X(18)30491-1},
journal = {The Lancet Global Health},
pages = {e337--e346},
title = {Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis},
url = {http://dx.doi.org/10.1016/S2214-109X(18)30491-1},
volume = {7},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Pneumococcal conjugate vaccines (PCV) are highly protective against invasive pneumococcal disease caused by vaccine serotypes, but the burden of pneumococcal disease in low-income and middle-income countries is dominated by pneumonia, most of which is non-bacteraemic. We examined the effect of 10-valent PCV on the incidence of pneumonia in Kenya. METHODS: We linked prospective hospital surveillance for clinically-defined WHO severe or very severe pneumonia at Kilifi County Hospital, Kenya, from 2002 to 2015, to population surveillance at Kilifi Health and Demographic Surveillance System, comprising 45000 children younger than 5 years. Chest radiographs were read according to a WHO standard. A 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PCV10) was introduced in Kenya in January, 2011. In Kilifi, there was a three-dose catch-up campaign for infants (aged <1 year) and a two-dose catch-up campaign for children aged 1-4 years, between January and March, 2011. We estimated the effect of PCV10 on the incidence of clinically-defined and radiologically-confirmed pneumonia through interrupted time-series analysis, accounting for seasonal and temporal trends. FINDINGS: Between May 1, 2002 and March 31, 2015, 44771 children aged 2-143 months were admitted to Kilifi County Hospital. We excluded 810 admissions between January and March, 2011, and 182 admissions during nurses' strikes. In 2002-03, the incidence of admission with clinically-defined pneumonia was 2170 per 100000 in children aged 2-59 months. By the end of the catch-up campaign in 2011, 4997 (61·1%) of 8181 children aged 2-11 months had received at least two doses of PCV10 and 23298 (62·3%) of 37416 children aged 12-59 months had received at least one dose. Across the 13 years of surveillance, the incidence of clinically-defined pneumonia declined by 0·5% per month, independent of vaccine introduction. There was no secular trend in t
AU  - Silaba,M
AU  - Ooko,M
AU  - Bottomley,C
AU  - Sande,J
AU  - Benamore,R
AU  - Park,K
AU  - Ignas,J
AU  - Maitland,K
AU  - Mturi,N
AU  - Makumi,A
AU  - Otiende,M
AU  - Kagwanja,S
AU  - Safari,S
AU  - Ochola,V
AU  - Bwanaali,T
AU  - Bauni,E
AU  - Gleeson,F
AU  - Deloria,Knoll M
AU  - Adetifa,I
AU  - Marsh,K
AU  - Williams,TN
AU  - Kamau,T
AU  - Sharif,S
AU  - Levine,OS
AU  - Hammitt,LL
AU  - Scott,JAG
DO  - 10.1016/S2214-109X(18)30491-1
EP  - 346
PY  - 2019///
SN  - 2214-109X
SP  - 337
TI  - Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis
T2  - The Lancet Global Health
UR  - http://dx.doi.org/10.1016/S2214-109X(18)30491-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30784634
UR  - http://hdl.handle.net/10044/1/72258
VL  - 7
ER  -
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