Imperial College London
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Professor Thomas N Williams

Faculty of Medicine, Department of Surgery & Cancer

Chair in Haemoglobinopathy Research
 
 
 
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Contact

 

tom.williams Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Casals-Pascual:2006:10.1182/blood-2006-05-018697,
author = {Casals-Pascual, DJ},
doi = {10.1182/blood-2006-05-018697},
journal = {Blood},
pages = {2569--2577},
title = {Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo},
url = {http://dx.doi.org/10.1182/blood-2006-05-018697},
volume = {108},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Malarial anemia is a global public health problem and is characterized by a low reticulocyte response in the presence of life-threatening hemolysis. Although cytokines, in particular tumor necrosis factor-α (TNF-α), can suppress erythropoiesis, the grossly abnormal bone marrow morphology indicates that other factors may contribute to ineffective erythropoiesis. We hypothesized that the cytotoxic hemozoin (Hz) residues from digested hemoglobin (Hb) significantly contribute to abnormal erythropoiesis. Here, we show that not only isolated Hz, but also delipidated Hz, inhibits erythroid development in vitro in the absence of TNF-α. However, when added to cultures, TNF-α synergizes with Hz to inhibit erythropoiesis. Furthermore, we show that, in children with malarial anemia, the proportion of circulating monocytes containing Hz is associated with anemia (P < .001) and reticulocyte suppression (P = .009), and that this is independent of the level of circulating cytokines, including TNF-α. Plasma Hz is also associated with anemia (P < .001) and reticulocyte suppression (P = .02). Finally, histologic examination of the bone marrow of children who have died from malaria shows that pigmented erythroid and myeloid precursors are associated with the degree of abnormal erythroid development. Taken together, these observations provide compelling evidence for inhibition of erythropoiesis by Hz.
AU  - Casals-Pascual,DJ
DO  - 10.1182/blood-2006-05-018697
EP  - 2577
PY  - 2006///
SN  - 0006-4971
SP  - 2569
TI  - Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
T2  - Blood
UR  - http://dx.doi.org/10.1182/blood-2006-05-018697
UR  - https://ashpublications.org/blood/article/108/8/2569/22589/Suppression-of-erythropoiesis-in-malarial-anemia
UR  - http://hdl.handle.net/10044/1/111157
VL  - 108
ER  -
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