Imperial College London
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DrJamesBennett

Faculty of Medicine, School of Public Health

Statistical Manager
 
 
 
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1120Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhou:2023:10.1038/s41591-023-02610-2,
author = {Zhou, B and Sheffer, K and Bennett, J and Gregg, E and Danaei, G and Singleton, R and Shaw, J and Mishra, A and Lhoste, V and Carrillo-Larco, R and Kengne, AP and Phelps, N and Heap, R and Rayner, A and Stevens, G and Paciorek, C and Riley, L and Cowan, M and Savin, S and Vander, Hoorn S and Lu, Y and Pavkov, M and Imperatore, G and Aguilar, Salinas C and Ahmad, NA and Anjana, RM and Davletov, K and Farzadfar, F and González-Villalpando, C and Khang, Y-H and Kim, HC and Laatikainen, T and Laxmaiah, A and Mbanya, JC and Venkat, Narayan KM and Ramachandran, A and Wade, A and Zdrojewski, T and Ezzati, M},
doi = {10.1038/s41591-023-02610-2},
journal = {Nature Medicine},
pages = {2885--2901},
title = {Global variation in diabetes diagnosis and prevalence based on fasting glucose and haemoglobin A1c},
url = {http://dx.doi.org/10.1038/s41591-023-02610-2},
volume = {29},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes and whether those who were previously undiagnosed, and detected as having diabetes in survey screening, had elevated FPG, HbA1c, or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardised proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardised proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.
AU  - Zhou,B
AU  - Sheffer,K
AU  - Bennett,J
AU  - Gregg,E
AU  - Danaei,G
AU  - Singleton,R
AU  - Shaw,J
AU  - Mishra,A
AU  - Lhoste,V
AU  - Carrillo-Larco,R
AU  - Kengne,AP
AU  - Phelps,N
AU  - Heap,R
AU  - Rayner,A
AU  - Stevens,G
AU  - Paciorek,C
AU  - Riley,L
AU  - Cowan,M
AU  - Savin,S
AU  - Vander,Hoorn S
AU  - Lu,Y
AU  - Pavkov,M
AU  - Imperatore,G
AU  - Aguilar,Salinas C
AU  - Ahmad,NA
AU  - Anjana,RM
AU  - Davletov,K
AU  - Farzadfar,F
AU  - González-Villalpando,C
AU  - Khang,Y-H
AU  - Kim,HC
AU  - Laatikainen,T
AU  - Laxmaiah,A
AU  - Mbanya,JC
AU  - Venkat,Narayan KM
AU  - Ramachandran,A
AU  - Wade,A
AU  - Zdrojewski,T
AU  - Ezzati,M
DO  - 10.1038/s41591-023-02610-2
EP  - 2901
PY  - 2023///
SN  - 1078-8956
SP  - 2885
TI  - Global variation in diabetes diagnosis and prevalence based on fasting glucose and haemoglobin A1c
T2  - Nature Medicine
UR  - http://dx.doi.org/10.1038/s41591-023-02610-2
UR  - https://www.nature.com/articles/s41591-023-02610-2
UR  - http://hdl.handle.net/10044/1/107086
VL  - 29
ER  -
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