Publications

BibTex format

@article{Niespialowska-Steuden:2017:10.1007/s11239-017-1548-3,
author = {Niespialowska-Steuden, M and Markides, V and Farag, M and Jones, D and Hussain, W and Wong, T and Gorog, DA},
doi = {10.1007/s11239-017-1548-3},
journal = {Journal of Thrombosis and Thrombolysis},
pages = {413--426},
title = {Catheter ablation for AF improves global thrombotic profile and enhances fibrinolysis},
url = {http://dx.doi.org/10.1007/s11239-017-1548-3},
volume = {44},
year = {2017}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Patients with atrial fibrillation (AF) are atincreased risk of thrombotic events despite oral anticoagulation(OAC). Radiofrequency catheter ablation (RFCA) canrestore and maintain sinus rhythm (SR) in patients with AF.To assess whether RFCA improves thrombotic status. 80patients (71% male, 64±12y) with recently diagnosed AF,on OAC and scheduled to undergo RFCA or DC cardioversion(DCCV) were recruited. Thrombotic status was assessedusing the point-of-care global thrombosis test (GTT), before,and 4–6 weeks after DCCV and 3 months after RFCA. TheGTT first measures the time taken for occlusive thrombusformation (occlusion time, OT), while the second phase ofthe test measures the time taken to spontaneously dissolvethis clot through endogenous thrombolysis (lysis time, LT).3 months after RFCA, there was a significant reduction inLT (1994s [1560; 2475] vs. 1477s [1015; 1878]) in thosewho maintained SR, but not in those who reverted to AF. Atfollow-up, LT was longer in those in AF compared to thosein SR (AF 2966s [2038; 3879] vs. SR 1477s [1015; 1878]).RFCA resulted in no change in OT value, irrespective of hythm outcome. Similarly, there was no change in OT orLT in response to DCCV, irrespective of whether SR wasrestored. Successful restoration and maintenance of SR followingRFCA of AF is associated with improved globalthrombotic status with enhanced fibrinolysis. Larger studiesare required to confirm these early results and investigatewhether improved thrombotic status translates into fewerthromboembolic events.
AU  - Niespialowska-Steuden,M
AU  - Markides,V
AU  - Farag,M
AU  - Jones,D
AU  - Hussain,W
AU  - Wong,T
AU  - Gorog,DA
DO  - 10.1007/s11239-017-1548-3
EP  - 426
PY  - 2017///
SN  - 0929-5305
SP  - 413
TI  - Catheter ablation for AF improves global thrombotic profile and enhances fibrinolysis
T2  - Journal of Thrombosis and Thrombolysis
UR  - http://dx.doi.org/10.1007/s11239-017-1548-3
UR  - http://hdl.handle.net/10044/1/54960
VL  - 44
ER  -

Download

DrViasMarkides

Contact

Assistant

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)