Imperial College London
Dr Victoria Wright

DrVictoriaWright

Faculty of Medicine, Department of Infectious Disease

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3577v.wright

 
 
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Location

 

PaediatricsMedical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Willems:2023:10.1016/j.isci.2023.107257,
author = {Willems, E and Gloerich, J and Suppers, A and van, der Flier M and van, den Heuvel LP and van, de Kar N and Philipsen, RHLA and van, Dael M and Kaforou, M and Wright, VJ and Herberg, JA and Torres, FM and Levin, M and de, Groot R and van, Gool AJ and Lefeber, DJ and Wessels, HJCT and de, Jonge MI and PERFORM, consortium},
doi = {10.1016/j.isci.2023.107257},
journal = {iScience},
title = {Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens},
url = {http://dx.doi.org/10.1016/j.isci.2023.107257},
volume = {26},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection.
AU  - Willems,E
AU  - Gloerich,J
AU  - Suppers,A
AU  - van,der Flier M
AU  - van,den Heuvel LP
AU  - van,de Kar N
AU  - Philipsen,RHLA
AU  - van,Dael M
AU  - Kaforou,M
AU  - Wright,VJ
AU  - Herberg,JA
AU  - Torres,FM
AU  - Levin,M
AU  - de,Groot R
AU  - van,Gool AJ
AU  - Lefeber,DJ
AU  - Wessels,HJCT
AU  - de,Jonge MI
AU  - PERFORM,consortium
DO  - 10.1016/j.isci.2023.107257
PY  - 2023///
SN  - 2589-0042
TI  - Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens
T2  - iScience
UR  - http://dx.doi.org/10.1016/j.isci.2023.107257
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37520696
UR  - http://hdl.handle.net/10044/1/106557
VL  - 26
ER  -
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